Showing Clinical Research · 55–72 of 303
PTSD is both prevalent and debilitating. While Deep TMS has shown preliminary efficacy, exposure therapy remains the most efficacious, though limited, treatment in PTSD. The medial prefrontal cortex (mPFC) is implicated in extinction learning, suggesting that concurrent mPFC stimulation may enhance exposure therapy. Objective: This randomized controlled multicenter trial set out…
One third of the depressed patients are not improved by antidepressant drugs and psychological treatments, and there is a need for additional treatments. Repetitive transcranial magnetic stimulation (rTMS) is being developed towards an alternative in treatment-resistant depression. Deep transcranial stimulation (dTMS) with the Hesel-coil…
Evidence is accumulating in support of the use of TMS for the treatment of OCD. The anterior cingulate cortex (ACC) is the brain target of choice for OCD because it is central in the processing of negative emotions including fear and threat,…
Recently the H7 dTMS coil was FDA approved for adjunctive treatment of adults with OCD based a multicenter sham-controlled study 100 adults. Will these findings hold up in a naturalistic setting? Objective: Retrospective chart review of adolescent and adult patients who received…
dTMS for obsessive-compulsive disorder (OCD) with the H7 coil has been shown to be efficacious in pilot and multicenter double-blinded clinical trials. How do patients fair in a naturalistic setting? Objective: Retrospective patient chart review who received open label dTMS for OCD…
Deep transcranial magnetic stimulation (dTMS) is designed to stimulate broader and deeper brain regions than conventional TMS. While dTMS had emerged as a promising option for obsessive-compulsive disorder (OCD), high-quality evidence on its efficacy and safety in treatment-resistant OCD remained limited. Objective: This meta-analysis evaluated the efficacy and…
Brain morphological biomarkers could contribute to understanding the treatment response in patients with obsessive-compulsive disorder (OCD). Multimodal neuroimaging addresses this issue by providing more comprehensive information regarding neural processes and structures. Objective: The study aimed to investigate whether patients responsive to deep Transcranial Magnetic Stimulation (TMS)…
Obsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it. Deep transcranial magnetic stimulation (dTMS) stimulates dorsomedial prefrontal cortex and anterior cingulate cortex - two frontal brain networks implicated in OCD. Objective: The study aimed to identify a…
Aerobic exercise (AEx) is effective in reducing depressive symptoms whether employed singularly or with other anti-depressant treatments. The safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression is also well documented. Given the benefits of both AEx and rTMS individually, it seems plausible that…
MDD is the most common comorbidity with OCD; more than 50% of OCD patients meet lifetime criteria for MDD or dysthymia. Depression can significantly worsen OCD treatment outcomes and elevate the risk for suicide. While the multi-center-tested and FDA indicated Deep TMS treatment for OCD uses the H7 Coil to target dorsomedial prefrontal cortex…
The DSM-5 classifies MDD as a depressed mood or a loss of interest or pleasure in daily activities for more than two consecutive weeks. Due to the nature of symptoms associated with major depression, many studies have looked at the correlation between…
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique with few side effects that has been reported to be effective in the treatment of major depressive disorder (MDD). At present, no randomized controlled trials (RCT) have compared the efficacy and safety of rTMS delivered by the…
Depressed patients who fail pharmacotherapy and non-invasive brain stimulation, such as TMS and ECT, have limited treatment options. Because depression affects multiple cortical and subcortical networks, multifocal deep TMS (dTMS) may have efficacy in such patients. Methods: A 25 year-old-woman diagnosed with bipolar…
Currently available therapeutic modalities for alcohol use disorder (AUD) produce limited effect sizes, particularly when long-term relapse prevention is considered. Following recognition of AUD as a brain disease and advances in understanding of related pathological neural circuitries, methods that were developed to modulate brain…
TMS-EEG is a rapidly growing area that can be used to assess cortical activity in response to TMS pulses with high temporal resolution. Objective: To evaluate EEG features following single dTMS pulses as a potential biomarker for treatment outcome in MDD patients. Methods: 27 healthy controls and…
Chronic treatment resistant depression takes a substantial toll on patients' quality of life and alternative treatment options are limited. Objective: This prospective multicenter study evaluated the safety, tolerability and efficacy of four weeks of thrice-a-week deep transcranial magnetic stimulation (dTMS) in combination with selective serotonin reuptake…
One of the strategies used for optimizing rTMS treatment for depression is combining rTMS with other evidence-based modalities. The use of light for depression dates back to the beginnings of civilization. Since the first description of the syndrome of Seasonal affective disorder (SAD) and light therapy in the seminal paper by Rosenthal, Bright Light Therapy…
