Showing Clinical Research · 91–108 of 292
Deep transcranial magnetic stimulation (dTMS) is an emerging and promising treatment for major depression. In our study, we explored the effectiveness of a second antidepressant course of dTMS in major depression. Objective: To evaluate whether a second course of dTMS would be effective. Methods: Eight depressive patients who relapsed…
Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil…
Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for the treatment of post-stroke motor deficits. Objective: Here, we explore safety, feasibility, and potential effectiveness of high-frequency rTMS (HF-rTMS) delivered with the Hesed coil (H-coil) during active cycling on paretic lower extremity (LE)…
Deep transcranial magnetic stimulation (dTMS) is more beneficial in activating the leg muscle cortical representation. However, to date, no studies have evaluated the advantages of dTMS compared to repetitive transcranial magnetic stimulation (rTMS) in improving lower extremity motor function in subacute stroke patients. Objective:…
Clinical studies have shown the ability to treat neuropsychiatric disorders using H1 Coil Deep TMS. However, the electric field (E) distributions inside the brain induced by this coil when it is positioned on the scalp according to those clinical studies have not yet been estimated. Objective:…
Deep repetitive transcranial magnetic stimulation (DTMS), using the H7 coil, is an approved treatment for obsessive-compulsive disorder (OCD) by the United States Food and Drug Administration (US-FDA). The clinical efficacy and safety of accelerated regimens of DTMS have been previously studied extensively.…
Obsessive-compulsive disorder is one of the most common neuropsychiatric disorders with a higher lifetime prevalence than schizophrenia, often showing inadequate response to pharmacological and psychotherapeutic treatments. Objective: This study aimed to examine the efficacy of adjunctive deep transcranial magnetic stimulation (dTMS) in…
Obsessive-compulsive disorder (OCD) is a chronic debilitating mental illness with waxing and waning courses. The H7 coil used for deep repetitive transcranial magnetic stimulation (dTMS) is designed to produce deeper and broader neuronal stimulation in the dorsomedial prefrontal cortex and anterior cingulate…
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. Objective: To investigate which brain regions…
Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a…
Complex Regional Pain Syndrome (CRPS) is a pain disorder that can occur with or without nerve trauma, known as CRPS Type II and CRPS Type I, respectively. Recently, the role of cortical changes and maladaptive neuroplasticity in response to chronic pain has become…
Conventional rTMS has demonstrated efficacy in reducing MS associated fatigue and spasticity. The H1 dTMS coil is currently FDA approved for the treatment of depression has never been tested in MS patients. Objective: To report on dTMS treatment of a 55-year-old physician with MS associated fatigue, irritability, tingling and numbness on ulnar aspects of both…
Insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. Objective: This study investigated the potential efficacy of rTMS targeting the insula in alcohol addiction. Methods: Treatment-seeking alcohol-dependent patients (Diagnostic and Statistical Manual of Mental…
dTMS utilizes H coils that have the capacity to reach 4cm below the skull and stimulate the lower limb. This has shown efficacy in improving function in patients who have suffered cerebral strokes. Conventional rTMS has been efficacious in treating MS induced fatigue and dexterity. Objective: To report…
Excessive alcohol consumption is a global health concern, with an estimated 400 million people living with alcohol use disorder (AUD). Current treatments for AUD have limited efficacy and fail to address its diverse neurobiological underpinnings. There are at least two cortico-striatal circuits…
Negative symptoms of schizophrenia are disabling and respond inadequately to antipsychotic treatment. Hypofunctioning of cortical areas such as anterior cingulate cortex and medial prefrontal cortex has been implicated in negative symptoms. Repetitive transcranial magnetic stimulation is efficacious for the negative symptoms. Deep transcranial magnetic stimulation (dTMS)…
Alcohol Use Disorder (AUD) is associated with elevated brain response to cues. Recent studies have suggested that theta burst stimulation (TBS) to the MPFC can decrease reactivity to cues in a transdiagnostic manner. Objective: To evaluate the effect of continuous TBS as…
Negative symptoms of schizophrenia are disabling and often show inadequate response to antipsychotic treatment. Dysfunction in cortical regions such as the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) has been implicated in these symptoms. While repetitive transcranial magnetic stimulation (rTMS)…
