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Clinical Research

Showing Clinical Research  ·  91–108 of 262

  1. Objective Improvement in ADHD Symptoms Following dTMS to the Right Prefrontal Cortex: Two Cases

    A Tendler, E Sisko, N Rodriguez, M Turcone, H LaSalle-Ricci

    Brain Stimulation  ·  2015

    Deep transcranial magnetic stimulation (dTMS) has been proposed as a treatment method for patients with Attention Deficit/Hyperactivity Disorder (ADHD).  Objective: To report on the treatment of two unmedicated patients with severe ADHD, combined type, using the dTMS H7 coil over the right prefrontal cortex. …

    ADHD
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  2. Deep rTMS for ADHD

    Y Paz, K Friedwald, Y Levkovitz, A Zangen, U Alyagon, A Segev, H Maoz, M Koubi, et al.

    Brain Stimulation  ·  2017

    Studies of the pathophysiology of ADHD (Attention Deficit Hyperactive Disorder) have exemplified hemispheric asymmetry that possibly typifies ADHD patients from controls with right prefrontal under activation. Recent studies support possible effectiveness of rTMS (repetitive transcranial magnetic stimulation) as treatment for ADHD. Deciding about the target for stimulation is complex as there is…

    ADHD
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  3. Safety and efficacy of Deep TMS for adolescent depression based on large real-world data analysis

    Yiftach Roth, Aron Tendler, Gaby S. Pell, TeeJay Tripp, Philip Yam,  Dianne DeKeyser, Mah Mekolle, Jayson Tripp, et al.

    Psychiatry Research  ·  2025

    Adolescent depression is a critical and growing public health concern, with high rates of treatment resistance and limited effective interventions. Deep Transcranial Magnetic Stimulation (Deep TMS) has been previously validated for adults, but data on its use in adolescents remain limited. Objective:To…

    Depression
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  4. Efficacy and Safety of Deep Transcranial Magnetic Stimulation Versus High-Frequency Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder: A Systematic Review

    Nan Zhang, Yu Mo, Xian-Jun Lan, Qi-Man Liu, Wen-Xiu Li, Xing-Bing Huang, Hua-Wang Wu, Shi-Chao Xu, et al.

    Current Behavioral Neuroscience Reports

    This systematic review aimed to evaluate and compare the safety and effectiveness of deep transcranial magnetic stimulation (dTMS) with high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for individuals diagnosed with major depressive disorder (MDD).  The study was motivated by the inconsistent findings of prior studies comparing  dTMS and HF-rTMS  for depression treatment. The…

    Depression
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  5. The Clinical Efficacy of Accelerated Deep Repetitive Transcranial Magnetic Stimulation in Depression and Obsessive-Compulsive Disorder: Multi-centric Real-World Observational Data

    Aswin K. Mudunuru, M S. Reddy, Kartik Valipay, Balaji S. A, Madhiha M, Chandresh N, Chandrasekhar K, Prasad R. Gundugurti

    Cureus  ·  2024

    Of late, the interest in accelerated treatment protocols in repetitive transcranial magnetic stimulation (TMS) for the treatment of depression and obsessive-compulsive disorder (OCD) has been gaining momentum. Studies have already found that the patterned theta burst stimulation is non-inferior to the standard…

    OCD
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  6. Deep TMS for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness

    Michelle Thai, Aparna U. Nair, Bonnie Klimes-Dougan, C. Sophia Albott, Thanharat Silamongkol, Michelle Corkrum, Dawson Hill, Justin W. Roemer, et al.

    Thai, et al. Journal of Affective Disorders  ·  2024

    Transcranial magnetic stimulation (TMS) is an intervention for treatment-resistant depression (TRD) that modulates neural activity. Deep TMS (dTMS) can target not only cortical but also deeper limbic structures implicated in depression. Although TMS has demonstrated safety in adolescents, dTMS has yet to…

    Depression
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  7. Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial

    Tyler S. Kaster, Zafiris J. Daskalakis, Yoshihiro Noda, Yuliya Knyahnytska, Jonathan Downar, Tarek K. Rajji, Yechiel Levkovitz, Abraham Zangen, et al.

    Neuropsychopharmacology  ·  2018

    Late-life depression (LLD) is a growing worldwide problem due to demographic changes, with limited treatment options due to high rates of pharmacotherapy adverse effects, accessibility of psychotherapy, and tolerability of electroconvulsive therapy. Novel neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS),…

    Depression
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  8. Never Too Late: Safety and Efficacy of Deep TMS for Late-Life Depression

    Yiftach Roth, Faisal Munasifi, Steven A. Harvey, Geoffrey Grammer, Colleen A. Hanlon and Aron Tendler

    Journal of Clinical Medicine  ·  2024

    Repetitive transcranial magnetic stimulation (rTMS) is an effective and well-established treatment for major depressive disorder (MDD). Deep TMS utilizes specially designed H-Coils to stimulate the deep and broad cerebral regions associated with the reward system. The improved depth penetration of Deep TMS…

    Depression
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  9. Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study

    Nathaniel A. Shanok, Sabrina Muzac, Leah Brown, Melissa Barrera, Raul Rodriguez

    Psychopharmacology  ·  2024

    Major Depressive Disorder (MDD) is a pervasive psychiatric condition effecting approximately 21 million adults in the U.S. (8.4%). An estimated 30–60% of patients are resistant to traditional treatment approaches (medications and talk-therapy), alluding to the need for additional options. Two promising treatment…

    Depression
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  10. Treatment strategies for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A network meta-analysis of randomised controlled trials

    Satish Suhasa, Palash Kumar Malob, Vijay Kumara, Thomas Gregor Issaca, Nellai K. Chithraa, Binukumar Bhaskarapillaib, Y. C. Janardhan Reddyaand Naren P. Rao

    THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY2023, VOL. 24, NO. 2, 162–177

    In the last couple of decades, newer treatment modalities, including neuromodulation through brain stimulation and psychosurgery have been examined to treat SRI-resistant OCD. A systematic review of brain stimulation treatments for resistant OCD suggested the efficacy of low-frequency TMS over the supplementary…

    OCD
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  11. Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder

    Rodrigo Moraga-Amaro, Paula Muñoz, Tomás Villalobos, Sergio Linsambarth, Francisco Maldonado, Valeria Meirone, Bruno Femopase, Jimmy Stehberg

    Psychiatry Research  ·  2023

    Anxiety disorders, including occupational stress and generalized anxiety disorder (GAD), are prevalent mental health conditions with significant impacts on individuals' daily functioning and quality of life. Deep Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique that holds promise in alleviating…

    AnxietyOCD
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  12. Depressive symptoms during deep transcranial magnetic stimulation or sham treatment for obsessive-compulsive disorder

    Orri Smárason,  Peter J. Boedeker,  Andrew G. Guzick,  Aron Tendler,  Sameer A. Sheth,  Wayne K. Goodman,  Eric A. Storch

    Journal of Affective Disorders  ·  2024

    Evidence suggests that depressive symptoms tend to improve concurrently with obsessive-compulsive disorder (OCD) symptoms during cognitive behavioral therapy (CBT), despite depression not being the primary target of intervention. Studies examining the temporal or mediational relationships of OCD and depressive symptoms have indicated…

    DepressionOCD
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  13. Durability of Deep Transcranial Magnetic Stimulation for Veterans with Treatment-Resistant Depression with Comorbid Suicide Risk and PTSD Symptoms

    Robert Hickson, Max W. Simonsen, Kenneth J. Miller, Michelle R. Madore

    Psychiatry Research  ·  2024

    The background highlights the challenges faced by veterans with TRD, suicide risk, and PTSD symptoms, emphasizing the need for effective and durable treatment options. Objective: The primary objective is to assess the durability of deep transcranial magnetic stimulation in improving symptoms of…

    DepressionPTSD
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  14. Are There Stages of Depression?

    It is normal for people to feel sad occasionally or have less enthusiasm for tasks that they once loved to do. However, when these feelings persist for an extended period, they may be a symptom of depression. Depression isn’t a defect of…

    Depression
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  15. Comparison of the analgesic effects of “superficial” and “deep” repetitive transcranial magnetic stimulation in patients with central neuropathic pain: a randomized sham-controlled multicenter international crossover study

    Didier Bouhassira, Frédérique Jazat-Poindessous, Nadine Farnes, Claire Franchisseur, Audun Stubhaug, Julie Bismuth, Jean-Pascal Lefaucheur, Per Hansson, et al.

    Pain  ·  2023

    We conducted a direct comparison of the analgesic effects resulting from "superficial" and "deep" repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex in patients with central neuropathic pain. A total of fifty-nine consecutive patients were randomly assigned to receive…

    Pain
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  16. Deep magnetic stimulation targeting the medial prefrontal and anterior cingulate cortices for methamphetamine use disorder: a randomised, double-blind, sham-controlled study

    Di Zhao, Ningning Zeng, Hang-Bin Zhang, Yi Zhang, Jiatong Shan, Huichun Luo, Abraham Zangen, and Ti-Fei Yuan

    General Psychiatry  ·  2023

    Prior research has underscored the importance of cravings in substance use disorders (SUDs) and the potential of repetitive transcranial magnetic stimulation (rTMS) in mitigating these cravings. Crucial brain regions, including the medial prefrontal cortex (MPFC) and anterior cingulate cortex (ACC), are implicated…

    Addiction
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  17. Deep Transcranial Magnetic Stimulation in combination with symptoms provocation: An effective treatment in patients with treatment-resistant Body Dysmorphic Disorder?

    Michele Di Ponzio, Stefano Pallanti

    Neuroscience Applied  ·  2023

    Body Dysmorphic Disorder (BDD) involves an excessive preoccupation with a perceived physical flaw, leading to impaired functioning. There is currently no FDA-approved treatment for BDD, and many patients do not respond to standard therapies. Neuromodulation, particularly deep Transcranial Magnetic Stimulation (dTMS), emerges…

    BDD
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  18. Past, present, and future of deep transcranial magnetic stimulation: A review in psychiatric and neurological disorders

    Jin-Ling Cheng, Cheng Tan, Hui-Yu Liu, Dong-Miao Han, and Zi-Cai Liu

    World Journal of Psychiatry  ·  2023

    Deep transcranial magnetic stimulation (dTMS) represents an innovative non-invasive neuromodulation method built upon repetitive transcranial magnetic stimulation technology. The novel H-coil brings notable benefits to the treatment and mechanistic exploration of psychiatric and neurological disorders, attributed to its ability to stimulate deep…