Mental Health / Psychiatry
Peer-reviewed studies and reviews on Deep TMS for Addiction.
Showing Addiction · 1–18 of 39
Cocaine dependence is a substantial public health problem. Objective: The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods: Seven men with CUD and…
Tobacco smoking remains a leading preventable cause of morbidity and mortality worldwide. Deep transcranial magnetic stimulation (DTMS) using the H4 coil targets addiction-related circuits within the bilateral insula and prefrontal cortex and has demonstrated safety and efficacy in reducing smoking craving. However,…
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for several mental health conditions including substance use disorders. Symptom provocation before rTMS is hypothesized to activate disease-related neurocircuitry and enhance treatment effects. For addiction, craving induction is frequently used before treatment, but…
In 2020, Deep Transcranial Magnetic Stimulation (Deep TMS) gained FDA clearance for short-term smoking cessation, demonstrating efficacy comparable to pharmacotherapies with minimal side effects. Objective: This Phase IV registry study aimed to assess the real-world feasibility and efficacy of Deep TMS for…
Pathological gambling is classified in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, as an impulse- control disorder. Several studies showed positive preliminary results using TMS to treat addictions. Because TMS is a potential treatment for addictions, and because frontal cortex activity may be abnormal in pathological gamblers compared…
Cue-Restricted Smoking (CRS) is a behavioral technique for smoking cessation that has shown efficacy as an adjunct to pharmacotherapy. In CRS, individuals limit smoking to a standing position while facing a wall in an isolated environment devoid of sensory stimulation. Objective: This…
Chronic cocaine consumption is associated with a decrease in mesolimbic dopamine transmission that maintains drug intake. TMS is gaining reliability, a useful therapeutic tool in drug addiction, since it can modulate cortico-limbic activity resulting in reduction of drug craving. Objective: This study…
Behavioral and neurobiological abnormalities in addiction and obesity have led to the theory of food addiction in obesity (FAOB) and brain-behavior association studies. Transcranial magnetic stimulation (TMS) studies and treats various brain disorders. Cortico-cortical paired associative stimulation (ccPAS) TMS protocol, in which…
Current approved therapies for smoking cessation have modest long-term effects for abstinence. The insular cortex has been identified by preclinical and clinical studies as a critical target for addiction treatment. Insula functions can be modulated non-invasively using brain stimulation. Objective: To describe a protocol for deep repetitive…
Cocaine dependence is a substantial public health problem. Objective: The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods: Seven men with CUD and no concurrent…
There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments…
Currently available therapeutic modalities for alcohol use disorder (AUD) produce limited effect sizes, particularly when long-term relapse prevention is considered. Following recognition of AUD as a brain disease and advances in understanding of related pathological neural circuitries, methods that were developed to modulate brain…
Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil…
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. Objective: To investigate which brain regions…
Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a…
Insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. Objective: This study investigated the potential efficacy of rTMS targeting the insula in alcohol addiction. Methods: Treatment-seeking alcohol-dependent patients (Diagnostic and Statistical Manual of Mental…
Excessive alcohol consumption is a global health concern, with an estimated 400 million people living with alcohol use disorder (AUD). Current treatments for AUD have limited efficacy and fail to address its diverse neurobiological underpinnings. There are at least two cortico-striatal circuits…
Alcohol Use Disorder (AUD) is associated with elevated brain response to cues. Recent studies have suggested that theta burst stimulation (TBS) to the MPFC can decrease reactivity to cues in a transdiagnostic manner. Objective: To evaluate the effect of continuous TBS as…
