Journal: Current Topics in Behavioral Neuroscience (2025)
Authors: Ygael N and Zangen A
Background:
Currently available therapeutic modalities for alcohol use disorder (AUD) produce limited effect sizes, particularly when long-term relapse prevention is considered. Following recognition of AUD as a brain disease and advances in understanding of related pathological neural circuitries, methods that were developed to modulate brain activity represent a promising treatment option. Indeed, brain stimulation procedures that are already being used in clinical setups for various psychiatric and neurological disorders following approval by the FDA and other regulatory bodies can target neural circuitries associated with the pathophysiology of AUD and have been shown to affect addictive behaviors.
Objective:
This chapter reviews studies evaluating the potential of brain stimulation methods to affect symptoms of AUD and recommends future directions for development of treatments for AUD using such interventions
Methods:
This narrative review summarizes preclinical and clinical studies evaluating brain stimulation approaches for alcohol use disorder, with a focus on their effects on craving, alcohol consumption, relapse, and relevant neural circuits.
Results:
While AUD treatment is yet to be optimized, this chapter indicates that adding brain stimulation to standard treatments can positively affect the outcome.
Conclusions:
As in the case of nicotine, the context in which the individual attempts abstinence from alcohol is highly challenging. Moderate alcohol consumption is a legitimate behavior in many cultures, and there is a widespread availability of drinks, drinking opportunities, and alcohol-related stimuli. Repeated exposure to alcohol cues can trigger craving and seeking behavior and eventually lead to complete relapse. Thus, brain stimulation protocols are suggested to be a part of more holistic therapeutic programs, which also include behavioral therapy, support groups, and the use of established pharmacological interventions when needed.
Full Publication: Modulation of Alcohol Use Disorder by Brain Stimulation | Springer Nature Link
