Showing Clinical Research · 1–18 of 295
Several different H-coils have been evaluated for the treatment of a variety of psychiatric and neurological disorders, including major depression, addiction, and blepharospasm, with encouraging results. This has prompted the development of novel H-coils designed to target specific brain regions, and diseases,…
Suicide is the 10th leading cause of death in US adults. Standard once-daily repetitive transcranial magnetic stimulation (rTMS) can reduce suicidal ideation. Yet, antidepressant and anti-suicidal effects often take several weeks to emerge, while rapid improvement is often required. Accelerated TMS has…
Because several targets of s-TMS studies play an important role in cognitive performance, the excitation or inhibition of these cortical areas could impair the patient’s performance in certain cognitive domains. Long-term studies assessing the effects of TMS on cognition have, in fact, shown…
Cannabis use disorder (CUD) is a significant public health problem and no medical treatments have received regulatory approval to date. Deep repetitive transcranial magnetic stimulation (dTMS) provides brief powerful bursts of electromagnetic stimulation to brain networks implicated in psychiatric disorders and the…
rTMS can decrease cravings for drugs in a cue dependent fashion. dTMS is efficacious in smoking cessation with sustained quitting when combined with exposure therapy. However, no studies have utilized real world exposure to increase cravings prior to treatment with cocaine use…
Cocaine dependence is a substantial public health problem. Objective: The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods: Seven men with CUD and…
The H-coils are a new development in transcranial magnetic stimulation (TMS) research, allowing direct stimulation of deeper neuronal pathways than does standard TMS. Objective: This study assessed possible health risks, and some cognitive and emotional effects, of two H-coil versions designed to…
Late stages of Lyme disease include cognitive impairment, such as memory loss, slowed handling of information and substandard abstract reasoning. High frequency deep transcranial magnetic stimulation (dTMS) over the left prefrontal cortex (lPFC) has been shown to improve cognitive functioning for patients…
Brain network dysfunction, particularly within the default mode network (DMN), is an increasingly apparent contributor to the clinical progression of Alzheimer's disease (AD). Repetitive transcranial magnetic stimulation (rTMS) can target key DMN hubs, maintain signaling function, and delay or improve clinical outcomes…
Focal rTMS has been applied to improve cognition in Alzheimer's disease (AD) with conflicting results. H Coils are suitable for targeting wider neuronal structures compared with traditional Figure-8 coils. In particular, the H2 Coil stimulates simultaneously the frontal-parietal-temporal lobes bilaterally. Objective: Evaluate…
Growing evidence highlights the crucial role of gut microbiota in affecting different aspects of obesity. Potential mechanisms for microbial control over eating behavior include microbiota influence on reward and satiety pathways, neurotransmitters release, and hypothalamic-pituitary-adrenal (HPA) axis modulation. dTMS is a methodology proved to be effective in modulating…
Obesity has reached epidemic proportions, becoming a global health concern. Promising results have been obtained by the application of Deep TMS in reducing nicotine dependence, alcohol craving, and cocaine abuse. Consistent with the dysregulation of the prefrontal cortex inhibitory control and brain…
Anorexia nervosa (AN) is a complex disorder of unknown etiology, characterized by obsessions and compulsions around body shape, weight, and calorie intake. In the course of AN, 10%-30% will recover, while the rest will develop a treatment-resistant course with a high mortality…
Obesity is known to be associated with an altered thermoregulation as well as a dysregulation of sympathetic nervous system (SNS). Considering the ability of deep transcranial magnetic stimulation (dTMS) to modulate the SNS, we hypothesized a potential role of dTMS in affecting…
In obesity, metabolic and voluntary factors regulate appetite, and a dysregulation of the reward pathway was demonstrated in all addiction disorders. Deep transcranial magnetic stimulation (dTMS) is already used to modulate cerebral dopamine activation in neuro-psychiatric diseases. Objective: To assess the acute…
Seizures are rare during repetitive transcranial magnetic stimulation (rTMS) treatment, but estimating risk is difficult because of study heterogeneity and sampling limitations. Moreover, there are few studies comparing rates between device manufacturers. Objective: The objective of this study was to calculate rTMS…
Major Depressive Disorder (MDD) and Alzheimer's disease (AD) represent two of the most prevalent diseases worldwide. Notably, it is estimated that 30%-50% of individuals with AD have co-occurring MDD and there are overlapping symptoms across numerous domains. Methods: In this pilot study,…
The optimal dose (number of pulses per session) of repetitive transcranial magnetic stimulation (rTMS), using the H-coil, in major depressive disorder (MDD) has not previously been reported. Objective: To explore the relationship between rTMS dose and antidepressant effect, and collect data for…
