Clinical Research
Peer-reviewed studies and reviews on Deep TMS for Neurologic Conditions.
Showing Neurologic Conditions · 1–18 of 49
Acute brain ischemia causes changes in several neural networks and related cortico-subcortical excitability, both in the affected area and in the apparently spared contralateral hemisphere. The modulation of these processes through modern techniques of noninvasive brain stimulation, namely repetitive transcranial magnetic stimulation (rTMS), has…
Stroke is a leading cause of morbidity and mortality among elderly populations worldwide. During the early phase of stroke, restoring blood circulation is of utmost importance to protect neurons from further injury. Once the initial condition is stabilized, various rehabilitation techniques can be applied…
Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful…
Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for the treatment of post-stroke motor deficits. Objective: Here, we explore safety, feasibility, and potential effectiveness of high-frequency rTMS (HF-rTMS) delivered with the Hesed coil (H-coil) during active cycling on paretic lower extremity (LE)…
Deep transcranial magnetic stimulation (dTMS) is more beneficial in activating the leg muscle cortical representation. However, to date, no studies have evaluated the advantages of dTMS compared to repetitive transcranial magnetic stimulation (rTMS) in improving lower extremity motor function in subacute stroke patients. Objective:…
Clinical studies have shown the ability to treat neuropsychiatric disorders using H1 Coil Deep TMS. However, the electric field (E) distributions inside the brain induced by this coil when it is positioned on the scalp according to those clinical studies have not yet been estimated. Objective:…
Complex Regional Pain Syndrome (CRPS) is a pain disorder that can occur with or without nerve trauma, known as CRPS Type II and CRPS Type I, respectively. Recently, the role of cortical changes and maladaptive neuroplasticity in response to chronic pain has become…
Conventional rTMS has demonstrated efficacy in reducing MS associated fatigue and spasticity. The H1 dTMS coil is currently FDA approved for the treatment of depression has never been tested in MS patients. Objective: To report on dTMS treatment of a 55-year-old physician with MS associated fatigue, irritability, tingling and numbness on ulnar aspects of both…
dTMS utilizes H coils that have the capacity to reach 4cm below the skull and stimulate the lower limb. This has shown efficacy in improving function in patients who have suffered cerebral strokes. Conventional rTMS has been efficacious in treating MS induced fatigue and dexterity. Objective: To report…
Low frequency (≤1 Hz) repetitive transcranial magnetic stimulation (rTMS) has been shown to suppress cortical excitability and is beginning to be trialed for the treatment of refractory epilepsy. Objective: As a step toward a larger trial, the current pilot study was aimed to…
Neurodegenerative diseases such as Parkinson's disease (PD) are becoming increasingly prevalent, necessitating diverse treatment options to manage symptoms. The effectiveness of these treatments depends on accurate and sensitive diagnostic methods. Objective: This exploratory pilot study explores the use of eye tracking and compares it to neuropsychological…
Freezing of Gait (FOG) is one of the most debilitating gait impairments in Parkinson's disease (PD), leading to increased fall risk and reduced health-related quality of life. The utility of parkinsonian medications is often limited in the case of FOG and it frequently becomes dopamine resistant.…
Benign essential blepharospasm (BEB) is a common form of focal dystonia. Besides pathology in the basal ganglia, accumulating evidence suggests pathologic changes in the anterior cingulate cortex (ACC). Objective: We conducted the present study to examine whether clinical and electrophysiologic effects of rTMS over the ACC…
Deep transcranial magnetic stimulation (dTMS) has been proposed as a treatment method for patients with Attention Deficit/Hyperactivity Disorder (ADHD). Objective: To report on the treatment of two unmedicated patients with severe ADHD, combined type, using the dTMS H7 coil over the right prefrontal cortex. …
Studies of the pathophysiology of ADHD (Attention Deficit Hyperactive Disorder) have exemplified hemispheric asymmetry that possibly typifies ADHD patients from controls with right prefrontal under activation. Recent studies support possible effectiveness of rTMS (repetitive transcranial magnetic stimulation) as treatment for ADHD. Deciding about the target for stimulation is complex as there is…
We conducted a direct comparison of the analgesic effects resulting from "superficial" and "deep" repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex in patients with central neuropathic pain. A total of fifty-nine consecutive patients were randomly assigned to receive…
https://link.springer.com/article/10.1007/s12264-022-00919-5
To date, Deep TMS has shown promising results as an add-on treatment for Parkinson’s disease (PD) but not for non-idiopathic Parkinson Syndromes (PS). Objective: To investigate the safety and feasibility of Deep TMS in patients with different Parkinson syndromes and medical refractory…
