Journal: Multiple Sclerosis Journal (2019)
Authors: Leocani L, Chieffo R, Gentile A, Centonze D
Background:
Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful approach targeting central nervous system plasticity. Another driver of brain plasticity is non-invasive brain stimulation (NIBS), receiving recent attention in neurology, particularly for its potential synergy with neurorehabilitation and as add-on treatment for several neurological conditions, from pain to fatigue to sensorimotor and cognitive deficits.
Objective:
This review examines the evidence exploring the neurobiological basis of NIBS and its applications to MS-related conditions.
Methods:
Narrative review of the neurobiological mechanisms underlying non-invasive brain stimulation (NIBS) and the available evidence for its use in multiple sclerosis-related symptoms and rehabilitation.
Results:
NIBS may enhance neuroplasticity and has shown potential as an adjunct to rehabilitation for symptoms including pain, fatigue, sensorimotor impairment, and cognitive deficits in people with multiple sclerosis.
Conclusions:
NIBS is a promising approach for promoting plasticity and supporting rehabilitation in multiple sclerosis, but additional research is needed to establish optimal stimulation approaches and confirm clinical effectiveness.
Full Publication: Beyond rehabilitation in MS: Insights from non-invasive brain stimulation
