Showing Clinical Research · 37–54 of 292
Promising clinical benefits were observed with d-cycloserine (DCS) augmentation of intermittent theta-burst stimulation (iTBS), presumably by enhancing long-term potentiation (LTP) through NMDA receptor agonism (Cole et al., 2022). However, the applicability of this trial and accessibility of this approach are unknown. Ojective: N/A Methods: N/A Results: We…
Acute brain ischemia causes changes in several neural networks and related cortico-subcortical excitability, both in the affected area and in the apparently spared contralateral hemisphere. The modulation of these processes through modern techniques of noninvasive brain stimulation, namely repetitive transcranial magnetic stimulation (rTMS), has…
Stroke is a leading cause of morbidity and mortality among elderly populations worldwide. During the early phase of stroke, restoring blood circulation is of utmost importance to protect neurons from further injury. Once the initial condition is stabilized, various rehabilitation techniques can be applied…
Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful…
There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments…
In obsessive-compulsive disorder (OCD), glutamatergic neurotransmission dysfunction played key roles in pathophysiology. Objective: The current research assessed changes of neurometabolites in the bilateral striatum of OCD patients receiving low-frequency repetitive transcranial magnetic stimulation (rTMS) using 1H proton magnetic resonance spectroscopy (1H-MRS). Methods: 52 OCD…
With respect to TMS coils used in TMS, the strength of a magnetic field decreases as it travels from its source at a rate of R-3 or 1/R3, where R is the distance from the center of the coil. For a typical figure-8…
PTSD is both prevalent and debilitating. While Deep TMS has shown preliminary efficacy, exposure therapy remains the most efficacious, though limited, treatment in PTSD. The medial prefrontal cortex (mPFC) is implicated in extinction learning, suggesting that concurrent mPFC stimulation may enhance exposure therapy. Objective: This randomized controlled multicenter trial set out…
One third of the depressed patients are not improved by antidepressant drugs and psychological treatments, and there is a need for additional treatments. Repetitive transcranial magnetic stimulation (rTMS) is being developed towards an alternative in treatment-resistant depression. Deep transcranial stimulation (dTMS) with the Hesel-coil…
Evidence is accumulating in support of the use of TMS for the treatment of OCD. The anterior cingulate cortex (ACC) is the brain target of choice for OCD because it is central in the processing of negative emotions including fear and threat,…
Recently the H7 dTMS coil was FDA approved for adjunctive treatment of adults with OCD based a multicenter sham-controlled study 100 adults. Will these findings hold up in a naturalistic setting? Objective: Retrospective chart review of adolescent and adult patients who received…
dTMS for obsessive-compulsive disorder (OCD) with the H7 coil has been shown to be efficacious in pilot and multicenter double-blinded clinical trials. How do patients fair in a naturalistic setting? Objective: Retrospective patient chart review who received open label dTMS for OCD…
Deep transcranial magnetic stimulation (dTMS) is designed to stimulate broader and deeper brain regions than conventional TMS. While dTMS had emerged as a promising option for obsessive-compulsive disorder (OCD), high-quality evidence on its efficacy and safety in treatment-resistant OCD remained limited. Objective: This meta-analysis evaluated the efficacy and…
Brain morphological biomarkers could contribute to understanding the treatment response in patients with obsessive-compulsive disorder (OCD). Multimodal neuroimaging addresses this issue by providing more comprehensive information regarding neural processes and structures. Objective: The study aimed to investigate whether patients responsive to deep Transcranial Magnetic Stimulation (TMS)…
Obsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it. Deep transcranial magnetic stimulation (dTMS) stimulates dorsomedial prefrontal cortex and anterior cingulate cortex - two frontal brain networks implicated in OCD. Objective: The study aimed to identify a…
Aerobic exercise (AEx) is effective in reducing depressive symptoms whether employed singularly or with other anti-depressant treatments. The safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression is also well documented. Given the benefits of both AEx and rTMS individually, it seems plausible that…
MDD is the most common comorbidity with OCD; more than 50% of OCD patients meet lifetime criteria for MDD or dysthymia. Depression can significantly worsen OCD treatment outcomes and elevate the risk for suicide. While the multi-center-tested and FDA indicated Deep TMS treatment for OCD uses the H7 Coil to target dorsomedial prefrontal cortex…
