Showing Clinical Research · 109–126 of 303
Obsessive-compulsive disorder (OCD) is a chronic debilitating mental illness with waxing and waning courses. The H7 coil used for deep repetitive transcranial magnetic stimulation (dTMS) is designed to produce deeper and broader neuronal stimulation in the dorsomedial prefrontal cortex and anterior cingulate…
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. Objective: To investigate which brain regions…
Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a…
Complex Regional Pain Syndrome (CRPS) is a pain disorder that can occur with or without nerve trauma, known as CRPS Type II and CRPS Type I, respectively. Recently, the role of cortical changes and maladaptive neuroplasticity in response to chronic pain has become…
Conventional rTMS has demonstrated efficacy in reducing MS associated fatigue and spasticity. The H1 dTMS coil is currently FDA approved for the treatment of depression has never been tested in MS patients. Objective: To report on dTMS treatment of a 55-year-old physician with MS associated fatigue, irritability, tingling and numbness on ulnar aspects of both…
Insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. Objective: This study investigated the potential efficacy of rTMS targeting the insula in alcohol addiction. Methods: Treatment-seeking alcohol-dependent patients (Diagnostic and Statistical Manual of Mental…
dTMS utilizes H coils that have the capacity to reach 4cm below the skull and stimulate the lower limb. This has shown efficacy in improving function in patients who have suffered cerebral strokes. Conventional rTMS has been efficacious in treating MS induced fatigue and dexterity. Objective: To report…
Excessive alcohol consumption is a global health concern, with an estimated 400 million people living with alcohol use disorder (AUD). Current treatments for AUD have limited efficacy and fail to address its diverse neurobiological underpinnings. There are at least two cortico-striatal circuits…
Negative symptoms of schizophrenia are disabling and respond inadequately to antipsychotic treatment. Hypofunctioning of cortical areas such as anterior cingulate cortex and medial prefrontal cortex has been implicated in negative symptoms. Repetitive transcranial magnetic stimulation is efficacious for the negative symptoms. Deep transcranial magnetic stimulation (dTMS)…
Alcohol Use Disorder (AUD) is associated with elevated brain response to cues. Recent studies have suggested that theta burst stimulation (TBS) to the MPFC can decrease reactivity to cues in a transdiagnostic manner. Objective: To evaluate the effect of continuous TBS as…
Negative symptoms of schizophrenia are disabling and often show inadequate response to antipsychotic treatment. Dysfunction in cortical regions such as the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) has been implicated in these symptoms. While repetitive transcranial magnetic stimulation (rTMS)…
Low frequency (≤1 Hz) repetitive transcranial magnetic stimulation (rTMS) has been shown to suppress cortical excitability and is beginning to be trialed for the treatment of refractory epilepsy. Objective: As a step toward a larger trial, the current pilot study was aimed to…
Patients with schizophrenia have a high prevalence of cigarette smoking and respond poorly to conventional treatments, highlighting the need for new therapies. Objective: This was a mechanistic, proof-of-concept study using bilateral deep repetitive transcranial magnetic stimulation (dTMS) of insular and prefrontal cortices…
Neurodegenerative diseases such as Parkinson's disease (PD) are becoming increasingly prevalent, necessitating diverse treatment options to manage symptoms. The effectiveness of these treatments depends on accurate and sensitive diagnostic methods. Objective: This exploratory pilot study explores the use of eye tracking and compares it to neuropsychological…
Freezing of Gait (FOG) is one of the most debilitating gait impairments in Parkinson's disease (PD), leading to increased fall risk and reduced health-related quality of life. The utility of parkinsonian medications is often limited in the case of FOG and it frequently becomes dopamine resistant.…
TMS holds promise for posttraumatic stress disorder (PTSD); while recent randomized controlled trials have provided mixed evidence (e.g., [4–6]), large-scale effectiveness data strongly supports the use of standard TMS for those who have PTSD comorbid with MDD. Objective: This study examined the…
PTSD patients have hypo-activity in the mPFC during traumatic recall. Stimulating the mPFC with dTMS after an individualized traumatic script was effective in decreasing PTSD symptoms in a double blinded placebo-controlled study. Objective: A retrospective case series treating patients with PTSD comorbid with severe depression who were ineligible for a…
PTSD is both prevalent and debilitating. While Deep TMS has shown preliminary efficacy, exposure therapy remains the most efficacious, though limited, treatment in PTSD. The medial prefrontal cortex (mPFC) is implicated in extinction learning, suggesting that concurrent mPFC stimulation may enhance exposure therapy. Objective: This randomized controlled multicenter trial set out…
