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Clinical Research

A New Era in Brain Research

BrainsWay’s patented breakthrough treatment based on Deep TMS begins a new era in brain stimulation and research. This non-invasive and effective treatment activates deep brain structures by using directed electromagnetic fields that generate excitation or inhibition of neurons deep inside the brain.

BrainsWay’s technology is based on patents filed by the U.S. National Institutes of Health (NIH) and the company. The treatment has been enthusiastically embraced by the international academic community, with over 60 clinical trials in leading institutions worldwide.

Patented Coil Structure

BrainsWay’s technology is based on the H-Coil, which features a novel patented structure that maximizes electrical stimulation of deep brain regions and includes the following unique features: coil elements tangential to the head and close to target brain regions, flexible base suited to head shape, convergence of numerous electric pulses from various directions, coil elements parallel to target bundles and location of return paths of electrical impulses remote from target area.

BrainsWay’s technology is based on a patent registered by the U.S. National Institutes of Health (NIH). BrainsWay has an exclusive license from the NIH for both the patent and the technology.

Ideal for Research

BrainsWay’s Deep TMS technology includes a double-blind system that enables researchers to easily conduct randomized studies. The system includes smart cards that are randomized between the patients. At the beginning of each treatment, the patient’s individual smart card is inserted into the card reader, automatically activating either the real or the sham coil, which are both located in the patient’s head set. Both coils produce similar scalp sensations and acoustic artifact, so that neither the patient nor the caregiver knows whether the treatment taking place is real or sham.

Can Be Implemented in a Range of Clinical & Neuroscience Studies

BrainsWay’s technology can be used to stimulate a wide variety of brain regions and networks. It can easily be applied to diverse clinical applications by designing coils that target different locations, depths, directionalities & morphologies relevant to target neuronal structures, and usage of different protocols during treatment.

The following is a list of brain regions that have been stimulated in various studies using BrainsWay’s technology: lateral and medial prefrontal cortex (PFC) including ventral PFC, orbitofrontal cortex, right & left Insular cortex and entorhinal cortex, anterior cingulate cortex, posterior cingulate cortex, lateral and medial motor cortex, including deeper leg motor cortex, premotor cortex, supplementary motor area, precuneus, right and left temporal cortex structures, including fusiform face area (FFA) & superior temporal sulcus (STS), parietal cortex regions, occipital cortex regions, auditory cortex, visual cortex and cerebellum.

Going Deeper for Better Results

Studies have shown that the depth and wide range of brain stimulation significantly and positively impact the results, as is shown in the following quotes:

“Many behavioral manifestations of neurological and psychiatric diseases are not solely the result of abnormality in one isolated brain region but represent alterations in brain networks and connectivity.” (Fox et al. Neurolmage 2012(

“Deeper (ventral) PFC structures have significantly more connections with other reward system sites compared to superficial PFC”. (Leh et al., 2007)

“There is significant inter-individual variability in the exact location of DLPFC sites having functional connectivity with subgenual cingulate.” (Fox et al. Neuroimage 2012)

“Effective response to standard TMS in MDD is strongly correlated with resting state functional connectivity between DLPFC stimulation sites and subgenual cingulate.” (Fox et al. Biol. Psychiatry 2012).

“Individualized targeting becomes less important with larger stimulation field sizes.” (Fox et al. Biol. Psychiatry 2012)

Variety of Treatments for Research

AlzheImer’s Disease (AD)

Alzheimer’s disease is a major cause of severe cognitive decline in the aged. The primary cognitive

Autism

Autism is a complex developmental disability that typically appears during the first three years of life

Bipolar Disorder

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in

Chronic Pain

Neuropathy is common in the diabetic population, affecting approximately 50% of patients with long-lasting diseases. The

Major Depressive Disorder (MDD) Treatment

Major Depressive Disorder is a neuropsychiatric disorder that is expressed in emotional, physiological and behavioral effects.

Parkinson’s Disease

Parkinson’s disease is a degenerative disorder of the central nervous system, which progresses slowly and is

Post Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is an extreme anxiety response to a life-threatening situation, which often manifests

Schizophrenia (Negative Symptoms)

Anti-psychotic medications are often effective for the positive symptoms of schizophrenia, and allow many patients to

Post Stroke Rehabilitation

A brain stroke is the loss of brain function due to a disturbance in the blood

Multiple Sclerosis (MSC)

Multiple Sclerosis (MSc) is an inflammatory demyelinating condition of the central nervous system that is mostly

Obsessive Compulsive Disorder (OCD) Treatment

BrainsWay Introduces the First FDA Cleared (De-Novo) Non-invasive Medical Device for the Treatment of OCD

Smoking Cessation

Tobacco smoking is the leading cause of preventable death in developed countries. Smoking is not merely

Active Trials Articles BrainsWay Therapy Publications Download Brochure

Controlled trial of 1 Hz Deep transcranial magnetic stimulation for treatment of temporal lobe epilepsy

A Pilot Study to Determine the Safety and Efficacy of H-Coil Deep Transcranial magnetic Stimulation in treatment resistant Anorexia Nervosa

New Hope for Your Major Depressive Disorder (MDD)

7 August 2018

New Hope for Neuropathic Pain Patients

Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study

Deep TMS on Alcoholics: Effects on Cortisolemia and Dopamine Pathway Modulation. A Pilot Study

Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial

How Deep is the Deep Transcranial Magnetic Stimulation (dTMS)? Putative Stimulation of Reward Pathways in Substanceuse Disorders: A Systematic Review and Meta-Analysis

Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: A systematic review and meta-analysis

A Review of Brain Stimulation Methods to Treat SubstanceUse Disorders

Transcranial Magnetic Stimulation (TMS) in the Elderly

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

High Frequency Deep TMS over the Bilateral Insula is Associated with Increased Degree Centrality in the Prefrontal Cortex of Obese Subjects: Preliminary Evidence

Deep Transcranial Magnetic Stimulation Acutely ModulatesNeuro-EndocrinePathwaysUnderlyingObesity

Deep Transcranial Magnetic Stimulation Attenuates Depressive and Anxiety Symptoms Associated with Obesity

Effects of Deep Transcranial Magnetic Stimulation (dTMS) on Anti-inflammatory Gut Bacterial Species in Obesity

Can deep transcranial magnetic stimulation (dTMS) be used to treat substance use disorders (SUD)? A systematic review

Deep Transcranial Magnetic Stimulation Over the Medial Prefrontal and Anterior Cingulate Cortex Alters Brain Connectivity and Reduces Relapses to Alcohol Use

Benefits of Deep Transcranial Magnetic Stimulationin Alzheimer Disease: Case Series

Chieffo, R., De Prezzo, S., Houdayer, E., Nuara, A., Di Maggio, G., Coppi, E., & Leocani, L. (2014). Archives of physical medicine and rehabilitation.

This study examined the effect of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) on patients that suffer from stroke-induced impairment of the lower limb motor function. There were two treatment periods, each comprising 11 sessions over 3 weeks, and separated by a 4-week period. The study showed that Deep TMS could generate long-term improvements in the functioning of the lower limb. In this study it was demonstrated that Brainsway Deep Transcranial Magnetic Stimulation results in significant and long lasting alleviation of symptoms.

Repetitive Deep Transcranial Magnetic Stimulation Improves Verbal Fluency and Written Language in a Patient with Primary Progressive Aphasia-Logopenic Variant (LPPA)

Excitatory Deep Transcranial Magnetic Stimulation with H-Coil Over the Right Homologous Broca’s Region Improves Naming in Chronic Post-Stroke Aphasia

BrainsWay D (TMS) Therapy for Depression – What to Expect, from Start to Finish

Insomnia Caused by Antidepressants – Problems and Solutions

BrainsWay Therapy or Antidepressants?

Right Prefrontal Deep Tms Effects on Attention Symptoms: Behavioral Outcomes and Electrophysiological Correlates

Right Prefrontal Transcranial Magnetic Stimulation for Adults with ADHD: Electrophysiological Correlates and Prognostic Biomarkers

Deep Transcranial Magnetic Stimulation Over the Right Prefrontal Cortex Improves ADHD Symptoms: A Combined TMS-EEG Study

Randomised Sham-Controlled Study of High-Frequency Bilateral Deep Transcranial Magnetic Stimulation (dTMS) to Treat Adult Attention Hyperactive Disorder (ADHD): Negative Results

Effects of Repetitive Transcranial Magnetic Stimulation over Prefrontal Cortex on Attention in Psychiatric Disorders: A Systematic Review

Clinical and electrophysiological effects of two dTMS protocols in ADHD

Enhanced cognition and emotional recognition, and reduced obsessive compulsive symptoms in two adults with high-functioning autism as a result of deep Transcranial Magnetic Stimulation (dTMS): a case report

A Double-blind, Randomized Trial of Deep Repetitive Transcranial Magnetic Stimulation (rTMS) for Autism Spectrum Disorder

Deep Repetitive Transcranial Magnetic Stimulation Associated with Improved Social Functioning in a Young Woman withan Autism Spectrum Disorder

Interhemispheric Cortico-cortical Paired Associative Stimulation of the Prefrontal Cortex Jointly Modulates Frontal Asymmetry and Emotional Reactivity

Deep Transcranial Magnetic Stimulation for the Treatment of Addiction: Electric Field Distribution Modeling

The Role of Medial Prefrontal Cortex in Theory of Mind: A Deep rTMS Study

Prelimbic Stimulation Ameliorates Depressive-Like Behaviors and Increases Regional BDNF Expression in a Novel Drug-Resistant Animal Model of Depression

Inherited behaviors, BDNF expression and response to treatment in a novel multi factorial rat model for depression

Site-Specific Antidepressant Effects of Repeated Subconvulsive Electrical Stimulation: Potential Role of Brain-Derived Neurotrophic Factor

Transcranial magnetic stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens

Three-Dimensional Distribution of the Electric Field Induced in the Brain by Transcranial Magnetic Stimulation Using Figure-8 and Deep H-Coils

A Coil Design for Transcranial Magnetic Stimulation of Deep Brain Regions

Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-Coil

Comparison of superficial TMS and deep TMS for major depression

Glutamate-Mediated Blood–Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

Safety and Characterization of a Novel Multi-Channel TMS Stimulator

Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans

Modelling of the Electric Field Distribution in Deep Transcranial Magnetic Stimulation in the Adolescence, in the Adulthood, and in the Old Age

Electric field estimation in deep transcranial magnetic stimulation

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Prelimbic Stimulation Ameliorates Depressive-Like Behaviors and Increases Regional BDNF Expression in a Novel Drug-Resistant Animal Model of Depression

Site-Specific Antidepressant Effects of Repeated Subconvulsive Electrical Stimulation: Potential Role of Brain-Derived Neurotrophic Factor

Modulation of Cortical Excitability Induced By Repetitive Transcranial Magnetic Stimulation: Influence of Timing And Geometrical Parameters And Underlying Mechanisms

Bersani, F. S., Girardi, N., Sanna, L., Mazzarini, L., Santucci, C., Kotzalidis, G. D., & Girardi, P. (2013). Neurocase, 19(5), 451-457.

This case report examines the effect of Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) H-coil stimulation in a patient with bipolar depression. The patient was provided with 20 daily consecutive Transcranial Magnetic Stimulation sessions, as well as one session every 2 weeks, over 3 months after the initial treatment. In this patient, symptoms were significantly alleviated and cognition was significantly enhanced following treatment. Moreover, these beneficial effects were evident for 6 months post treatment.

H-coil repetitive transcranial magnetic stimulation for the treatment of bipolar depression: an add-on, safety and feasibility study

Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression

Deep Transcranial Magnetic Stimulation for treatment-resistant bipolar disorder: A case report of acute and maintenance efficacy

Treatment of Bipolar Disorder with Deep TMS: Results from a Double-Blind, Randomized, Parallel Group, Sham-ControlledClinicalTrial

Cognitive outcomes of TMS treatment in bipolar depression: Safety data from a randomized controlled trial

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex in depressive episodes of patients with Major Depressive Disorder, Bipolar Disorder I, and Major Depressive with Alcohol Use Disorders

dmPFC-ACC dTMS for Refractory Body Dysmorphic Disorder: Case Report

Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome / interstitial cystitis

Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine: A preliminary study

Deep TMS Augmentation Treatment for Fibromyalgia: A Safety and Feasibility Study

H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy

Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil

Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

Insular and anterior cingulate cortex deep stimulation for central neuropathic pain

Chieffo, R., De Prezzo, S., Houdayer, E., Nuara, A., Di Maggio, G., Coppi, E., & Leocani, L. (2014). Archives of physical medicine and rehabilitation.

Levkovitz, Y., Rabany, L., Harel, E. V., & Zangen, A. (2011). The International Journal of Neuropsychopharmacology, 14(07), 991-996.

This study examined the effect of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on schizophrenic patients. In the study, patients were given 20 daily Deep Transcranial Magnetic Stimulation sessions over the prefrontal cortex. The study demonstrated that brain stimulation using the H-coil significantly alleviates the negative symptoms of schizophrenia as well as enhancing cognition.

Levkovitz, Y., Harel, E. V., Roth, Y., Braw, Y., Most, D., Katz, L. N., & Zangen, A. (2009). Brain Stimulation, 2(4), 188-200.

This is the first clinical study using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil for deep brain stimulation. This large scale study examined the effect of H-coil on patients suffering from drug-resistant depression. The study found a significant improvement in HDRS scores in the cases of high-intensity stimulation. The study demonstrated that brain stimulation using the Brainsway Deep TMS H-coil results in significant alleviation of depressive symptoms in these patients.

Rosenberg, O., Roth, Y., Kotler, M., Zangen, A., & Dannon, P. (2011). Annals of general psychiatry, 10(1), 3.

This study examined the effect of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on auditory hallucinations of schizophrenic patients. Low-frequency Deep TMS was used to stimulate the left temporoparietal cortex over 10-20 sessions. The study showed a substantial improvement in HRS score as well as a smaller improvement in SAPS. The study demonstrated that Deep Transcranial Magnetic Stimulation using the H-coil significantly alleviates positive symptoms of schizophrenia.

Bersani, F. S., Girardi, N., Sanna, L., Mazzarini, L., Santucci, C., Kotzalidis, G. D., & Girardi, P. (2013). Neurocase, 19(5), 451-457.

Levkovitz, Y., Roth, Y., Harel, E. V., Braw, Y., Sheer, A., & Zangen, A. (2007). Clinical Neurophysiology, 118(12), 2730-2744.

This study examined possible effects of different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and different stimulation parameters on healthy individuals. Several parameters relating to health, cognitive and emotional issues were checked .Results were also compared to a standard coil (figure 8) and to a sham coil. This study demonstrated that brain stimulation using the H-coil is feasible, safe and without adverse consequences.

Alternate Day dTMS Combined with SSRIs for Chronic Treatment Resistant Depression: A Prospective Multicenter Study

Simultaneous Aerobic Exercise and rTMS: Feasibility of Combining Therapeutic Modalities to Treat Depression

Add-On High Frequency Deep Transcranial Magnetic Stimulation (dTMS) to Bilateral Prefrontal Cortex in Depressive Episodes of Patients With Major Depressive Disorder, Bipolar Disorder, and Major Depressive with Alcohol Use Disorders

Effectiveness of a Second Deep TMS in Depression: A Brief Report

Acute Reduction in Anxiety After Deep Transcranial Magnetic Stimulation (DTMS) in Unipolar Major Depression-a Systematic Review and Meta-Analysis

Background:

Major depressive disorder (MDD) is highly prevalent and has been associated with abnormalities in several brain areas (e.g., prefrontal cortex, insula, hippocampus) that have been shown to usually improve following clinical recovery. A significant number of MDD patients suffer from treatment-resistant depression (TRD). Deep transcranial magnetic stimulation (dTMS), a promising therapeutic intervention for managing TRD, has been shown to be well tolerated and associated with response and remission rates of 47% and 42%, respectively.

Objective:

To report the effects of a 4-week trial of dTMS on depressive and anxious symptoms as well as on brain activity in an adult patient with TRD.

Methods:

The protocol involved a pre-and a post-functional magnetic resonance imaging (fMRI) scan during which Mrs A had to perform a working memory task(i.e., n-back). Her baseline score on the 21-item Hamilton Depression Rating Scale (HAM-D21) was 24, indicating severe depressive symptoms.

Results:

Immediately after 4 weeks of daily dTMS treatment applied over the left dorsolateral prefrontal cortex (DLPFC), her HAM-D 21 score decreased to 13 (a 46% reduction), and 1 month later, it was 12 (a 50% reduction).Moreover, Mrs A’s accuracy scores on then-back task (i.e., 2-back condition) improved from 79% (baseline) to 96% (after dTMS treatment). At the neural level, Mrs A showed significantly increased brain activity in the working memory network(e.g., DLPFC, parietal cortex) during the execution of the 2-back condition after dTMS treatment compared to baseline.

Conclusions:

These findings are consistent with those of recent studies that have showed that dTMS applied to the left DLPFC is efficacious for treating depressed patients and may also improve their performance on a number of cognitive domains (e.g., sustained attention, visuospatial memory, cognitive planning).

Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Late-Life Depression: a Prospective Randomized Controlled Trial

Deep TMS in a Resistant Major Depressive Disorder: a Brief Report

Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex: Evaluation of Antidepressant and Cognitive Effects in Depressive Patients

Deep Transcranial Magnetic Stimulation (DTMS) in the Treatment of Major Depression: An Exploratory Systematic Review and Meta-analysis

Differential Effects of Deep TMS of the Prefrontal Cortex on Apathy and Depression

Augmenting Antidepressants With Deep Transcranial Magnetic Stimulation (dTMS) in Treatment-Resistant Major Depression

Personality Dimensions and Deep Repetitive Transcranial Magnetic Stimulation (dTMS) for Treatment-Resistant Depression: A Pilot Trial on Five-Factor Prediction of Antidepressant Response

Cognitive-Emotional Reactivation During Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex of Depressive Patients Affects Anti Depressant Outcome

Antidepressant Effectiveness of Deep Transcranial Magnetic Stimulation (dTMS) in Patients with Major Depressive Disorder (MDD) With or Without Alcohol Use Disorders (AUDs): A 6-Month, Open Label, Follow-up Study

Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Clinically-Relevant Outcomes of Deep Transcranial Magnetic Stimulation (dTMS) in Unipolar Major Depression: A Systematic Review and Meta-Analysis

Response to Deep TMS in Depressive Patients with Previous Electroconvulsive Treatment

H-coil Repetitive Transcranial Magnetic Stimulation for Treatment Resistant Major Depressive Disorder: An 18-week Continuation Safety and Feasibility Study

61% of Unmedicated Treatment Resistant Depression Patients Who Did Not Respond to Acute TMS Treatment Responded After Four Weeks of Twice Weekly deep TMS in the BrainsWay Pivotal Trial

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Major Depression: a Prospective Multicenter Randomized Controlled Trial

Clinical and Electrophysiological Outcomes of deep TMS Over the Medial Prefrontal and Anterior Cingulate Cortices in OCD Patients

Deep Transcranial Magnetic Stimulation of the Anterior Cingulate Cortex in Obsessive Compulsive Disorder Patients

Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study

Deep TMS on Alcoholics: Effects on Cortisolemia and Dopamine Pathway Modulation. A Pilot Study

Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial

How Deep is the Deep Transcranial Magnetic Stimulation (dTMS)? Putative Stimulation of Reward Pathways in Substanceuse Disorders: A Systematic Review and Meta-Analysis

Effectiveness of Deep Transcranial Magnetic Stimulation Combined with a Brief Exposure Procedure in Post-Traumatic Stress Disorder-A Pilot Study

H-coil repetitive transcranial magnetic stimulation for the treatment of bipolar depression: an add-on, safety and feasibility study

Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression

Deep Transcranial Magnetic Stimulation for treatment-resistant bipolar disorder: A case report of acute and maintenance efficacy

Treatment of Bipolar Disorder with Deep TMS: Results from a Double-Blind, Randomized, Parallel Group, Sham-ControlledClinicalTrial

Cognitive outcomes of TMS treatment in bipolar depression: Safety data from a randomized controlled trial

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex in depressive episodes of patients with Major Depressive Disorder, Bipolar Disorder I, and Major Depressive with Alcohol Use Disorders

Deep transcranial magnetic stimulationadd-on for treatment of negative symptomsand cognitive deficits of schizophrenia:a feasibility study

Double-blind, randomized sham controlled study of deep-TMS add-on treatment for negative symptoms and cognitive deficits in schizophrenia

Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: adouble-blind study

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: apreliminary open-label study

Deep-TMS Add-On Treatment for Intractable Tourette syndrome: A Feasibility Study

dmPFC-ACC dTMS for Refractory Body Dysmorphic Disorder: Case Report

Benefits of Deep Transcranial Magnetic Stimulationin Alzheimer Disease: Case Series

Enhanced cognition and emotional recognition, and reduced obsessive compulsive symptoms in two adults with high-functioning autism as a result of deep Transcranial Magnetic Stimulation (dTMS): a case report

A Double-blind, Randomized Trial of Deep Repetitive Transcranial Magnetic Stimulation (rTMS) for Autism Spectrum Disorder

Deep Repetitive Transcranial Magnetic Stimulation Associated with Improved Social Functioning in a Young Woman withan Autism Spectrum Disorder

Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome / interstitial cystitis

Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine: A preliminary study

Deep TMS Augmentation Treatment for Fibromyalgia: A Safety and Feasibility Study

H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy

Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil

Right Prefrontal Deep Tms Effects on Attention Symptoms: Behavioral Outcomes and Electrophysiological Correlates

Right Prefrontal Transcranial Magnetic Stimulation for Adults with ADHD: Electrophysiological Correlates and Prognostic Biomarkers

Deep Transcranial Magnetic Stimulation Over the Right Prefrontal Cortex Improves ADHD Symptoms: A Combined TMS-EEG Study

Randomised Sham-Controlled Study of High-Frequency Bilateral Deep Transcranial Magnetic Stimulation (dTMS) to Treat Adult Attention Hyperactive Disorder (ADHD): Negative Results

Retrospective evaluation of deep transcranial magnetic stimulation as add-on treatment for Parkinson’s disease

Excitatory Deep Repetitive Transcranial Magnetic Stimulation with H-coil as Add-on Treatment of Motor Symptoms in Parkinson’s Disease: An Open Label, Pilot Study

Repetitive deep transcranial magnetic stimulation for Motor symptoms in Parkinson’s disease: A feasibility study

Deep rTMS for Neuropsychiatric Symptoms of Huntington’sDisease: Case Report

Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue

H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

Bi-hemispheric Repetitive Transcranial Magnetic Stimulation for Upper Limb Motor Recovery in Chronic Stroke: A Feasibility Study

Deep Repetitive Transcranial Magnetic Stimulation with H-coil on Lower Limb Motorfunction after Stroke: a Pilot Study

Repetitive Deep Transcranial Magnetic Stimulation Improves Verbal Fluency and Written Language in a Patient with Primary Progressive Aphasia-Logopenic Variant (LPPA)

Excitatory Deep Transcranial Magnetic Stimulation with H-Coil Over the Right Homologous Broca’s Region Improves Naming in Chronic Post-Stroke Aphasia

Interhemispheric Cortico-cortical Paired Associative Stimulation of the Prefrontal Cortex Jointly Modulates Frontal Asymmetry and Emotional Reactivity

Deep Transcranial Magnetic Stimulation for the Treatment of Addiction: Electric Field Distribution Modeling

The Role of Medial Prefrontal Cortex in Theory of Mind: A Deep rTMS Study

Prelimbic Stimulation Ameliorates Depressive-Like Behaviors and Increases Regional BDNF Expression in a Novel Drug-Resistant Animal Model of Depression

Inherited behaviors, BDNF expression and response to treatment in a novel multi factorial rat model for depression

Site-Specific Antidepressant Effects of Repeated Subconvulsive Electrical Stimulation: Potential Role of Brain-Derived Neurotrophic Factor

Transcranial magnetic stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens

Three-Dimensional Distribution of the Electric Field Induced in the Brain by Transcranial Magnetic Stimulation Using Figure-8 and Deep H-Coils

A Coil Design for Transcranial Magnetic Stimulation of Deep Brain Regions

Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-Coil

Comparison of superficial TMS and deep TMS for major depression

Glutamate-Mediated Blood–Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

Safety and Characterization of a Novel Multi-Channel TMS Stimulator

Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans

Modelling of the Electric Field Distribution in Deep Transcranial Magnetic Stimulation in the Adolescence, in the Adulthood, and in the Old Age

Electric field estimation in deep transcranial magnetic stimulation

Sequential l-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst DTMS For Highly-Suicidal Treatment-Resistant Depression Patients

H1-coil Intermittent Theta Burst Stimulation For a Patient With a High Motor Threshold: Case Report

Alternative Antidepressant Deep Transcranial Magnetic Stimulation Protocols

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Prelimbic Stimulation Ameliorates Depressive-Like Behaviors and Increases Regional BDNF Expression in a Novel Drug-Resistant Animal Model of Depression

Site-Specific Antidepressant Effects of Repeated Subconvulsive Electrical Stimulation: Potential Role of Brain-Derived Neurotrophic Factor

Modulation of Cortical Excitability Induced By Repetitive Transcranial Magnetic Stimulation: Influence of Timing And Geometrical Parameters And Underlying Mechanisms

Potential Predictors of Depressive Relapse Following Repetitive Transcranial Magnetic Stimulation: A Systematic Review

Durability of antidepressant response to repetitive transcranial magnetic stimulation: systematic review and meta-analysis

Application of transcranial magnetic stimulation for major depression: Coil design and neuroanatomical variability considerations

Personality traits and antidepressant effects of deep repetitive transcranial magnetic stimulation (dTMS)

Alternative antidepressant deep transcranial magnetic stimulation protocols

What Intensity of Deep Transcranial Magnetic Stimulation is Necessary to Remit Treatment Resistant Depression

Antidepressant outcomes of highfrequency repetitive transcranial magnetic stimulation (rTMS) with F8-coil and deep transcranial magnetic stimulation (dTMS) with H1-coil in major depression: a systematic review and meta-analysis

A Novel Dual-Channel Deep Transcranial Magnetic Stimulator for Major Depressive Disorder

Efficacy and Safety of Deep Transcranial MagneticStimulation for Obsessive-Compulsive Disorder:A Prospective Multicenter RandomizedDouble-Blind Placebo-Controlled Trial

Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: A systematic review and meta-analysis

A Review of Brain Stimulation Methods to Treat SubstanceUse Disorders

Transcranial Magnetic Stimulation (TMS) in the Elderly

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

High Frequency Deep TMS over the Bilateral Insula is Associated with Increased Degree Centrality in the Prefrontal Cortex of Obese Subjects: Preliminary Evidence

Deep Transcranial Magnetic Stimulation Acutely ModulatesNeuro-EndocrinePathwaysUnderlyingObesity

Deep Transcranial Magnetic Stimulation Attenuates Depressive and Anxiety Symptoms Associated with Obesity

Effects of Deep Transcranial Magnetic Stimulation (dTMS) on Anti-inflammatory Gut Bacterial Species in Obesity

Can deep transcranial magnetic stimulation (dTMS) be used to treat substance use disorders (SUD)? A systematic review

Deep Transcranial Magnetic Stimulation Over the Medial Prefrontal and Anterior Cingulate Cortex Alters Brain Connectivity and Reduces Relapses to Alcohol Use

H-Coil Intermittent Theta Burst Stimulation for a Patient with a High Motor Threshold: Case Report

Sequential L-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst dTMS for Suicidal Highly Treatment Resistant Depression Patients

Repetitive transcranial magnetic stimulation in trauma-related conditions

Deep Transcranial Magnetic Stimulation for the Treatment of negative Symptoms in Schizophrenia: Beyond an Antidepressant Effect

Effects of Repetitive Transcranial Magnetic Stimulation over Prefrontal Cortex on Attention in Psychiatric Disorders: A Systematic Review

Clinical and electrophysiological effects of two dTMS protocols in ADHD

Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

Insular and anterior cingulate cortex deep stimulation for central neuropathic pain

Obsessive-Compulsive Disorder: Diagnosis and Treatment

Promising OCD Therapy for Treatment-Resistant Patients

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OCD and Mental Health in a Time of Illness

How to Choose the Right OCD Treatment and Expert

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Do I have OCD?

OCD Treatment Options That Avoid Pills and Invasive Procedures

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Making Sense of the TMS Procedure

What is BrainsWay Deep TMS?

Everything You Need to Know About BrainsWay TMS

How Does TMS Therapy Help Treat Mental Health Conditions?

Mental Health Support During the Coronavirus Outbreak

How Long Does Deep TMS Treatment Take?

BrainsWay-D patients brochure

H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

Deep rTMS for Neuropsychiatric Symptoms of Huntington’sDisease: Case Report

Levkovitz, Y., Harel, E. V., Roth, Y., Braw, Y., Most, D., Katz, L. N., & Zangen, A. (2009). Brain Stimulation, 2(4), 188-200.

Levkovitz, Y., Roth, Y., Harel, E. V., Braw, Y., Sheer, A., & Zangen, A. (2007). Clinical Neurophysiology, 118(12), 2730-2744.

Alternate Day dTMS Combined with SSRIs for Chronic Treatment Resistant Depression: A Prospective Multicenter Study

Simultaneous Aerobic Exercise and rTMS: Feasibility of Combining Therapeutic Modalities to Treat Depression

Background:

Objective:

To report the effects of a 4-week trial of dTMS on depressive and anxious symptoms as well as on brain activity in an adult patient with TRD.

Methods:

Results:

Conclusions:

Add-On High Frequency Deep Transcranial Magnetic Stimulation (dTMS) to Bilateral Prefrontal Cortex in Depressive Episodes of Patients With Major Depressive Disorder, Bipolar Disorder, and Major Depressive with Alcohol Use Disorders

Effectiveness of a Second Deep TMS in Depression: A Brief Report

Acute Reduction in Anxiety After Deep Transcranial Magnetic Stimulation (DTMS) in Unipolar Major Depression-a Systematic Review and Meta-Analysis

Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Late-Life Depression: a Prospective Randomized Controlled Trial

Deep TMS in a Resistant Major Depressive Disorder: a Brief Report

Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex: Evaluation of Antidepressant and Cognitive Effects in Depressive Patients

Deep Transcranial Magnetic Stimulation (DTMS) in the Treatment of Major Depression: An Exploratory Systematic Review and Meta-analysis

Differential Effects of Deep TMS of the Prefrontal Cortex on Apathy and Depression

Augmenting Antidepressants With Deep Transcranial Magnetic Stimulation (dTMS) in Treatment-Resistant Major Depression

Personality Dimensions and Deep Repetitive Transcranial Magnetic Stimulation (dTMS) for Treatment-Resistant Depression: A Pilot Trial on Five-Factor Prediction of Antidepressant Response

Cognitive-Emotional Reactivation During Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex of Depressive Patients Affects Anti Depressant Outcome

Antidepressant Effectiveness of Deep Transcranial Magnetic Stimulation (dTMS) in Patients with Major Depressive Disorder (MDD) With or Without Alcohol Use Disorders (AUDs): A 6-Month, Open Label, Follow-up Study

Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Clinically-Relevant Outcomes of Deep Transcranial Magnetic Stimulation (dTMS) in Unipolar Major Depression: A Systematic Review and Meta-Analysis

Response to Deep TMS in Depressive Patients with Previous Electroconvulsive Treatment

H-coil Repetitive Transcranial Magnetic Stimulation for Treatment Resistant Major Depressive Disorder: An 18-week Continuation Safety and Feasibility Study

61% of Unmedicated Treatment Resistant Depression Patients Who Did Not Respond to Acute TMS Treatment Responded After Four Weeks of Twice Weekly deep TMS in the BrainsWay Pivotal Trial

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Major Depression: a Prospective Multicenter Randomized Controlled Trial

Potential Predictors of Depressive Relapse Following Repetitive Transcranial Magnetic Stimulation: A Systematic Review

Durability of antidepressant response to repetitive transcranial magnetic stimulation: systematic review and meta-analysis

Application of transcranial magnetic stimulation for major depression: Coil design and neuroanatomical variability considerations

Personality traits and antidepressant effects of deep repetitive transcranial magnetic stimulation (dTMS)

Alternative antidepressant deep transcranial magnetic stimulation protocols

What Intensity of Deep Transcranial Magnetic Stimulation is Necessary to Remit Treatment Resistant Depression

Antidepressant outcomes of highfrequency repetitive transcranial magnetic stimulation (rTMS) with F8-coil and deep transcranial magnetic stimulation (dTMS) with H1-coil in major depression: a systematic review and meta-analysis

A Novel Dual-Channel Deep Transcranial Magnetic Stimulator for Major Depressive Disorder

What is TMS Treatment?

Making Sense of the TMS Procedure

What is BrainsWay Deep TMS?

Everything You Need to Know About BrainsWay TMS

Can You Overcome Treatment-Resistant Depression?

Using Magnetic Therapy for Depression Treatment

Major Depressive Disorder and TMS Treatment

Deep Transcranial Magnetic Stimulation for Depression

TMS for Depression and Anxiety

TMS for Depression

What Are the Options for Depression Treatment?

Obsessive-Compulsive Disorder: Diagnosis and Treatment

What Are the Options for OCD Treatment?

How Does TMS Therapy Help Treat Mental Health Conditions?

Major Depressive Disorder: Diagnosis and Treatment

5 OCD Treatment Ideas You Should Consider

Are there alternatives to OCD medication?

What is the Difference Between rTMS and dTMS?

What Are Obsessive-Compulsive Disorder Symptoms?

Taking Center Stage: How OCD Branched Out of Anxiety

Do I have OCD?

How Long Does Deep TMS Treatment Take?

The History of Depression

OCD Treatment Options That Avoid Pills and Invasive Procedures

Promising OCD Therapy for Treatment-Resistant Patients

OCD Medication and Neurosurgical Treatment Options

Depression in a Time of Illness: How a General Health Crisis Can Affect Your Depression

OCD and Mental Health in a Time of Illness

How to Choose the Right OCD Treatment and Expert

Not Just Hand-Washing: OCD Attributes You Should Know About

Mental Health Support During the Coronavirus Outbreak

The Day After Corona—Mental Health Mid and Post-Crisis

Alone with Your Thoughts: On Quarantine and Well-Being

How Your Personality Might Affect How You Handle COVID-19

How National Identity Might Affect How We Handle Corona

Bi-hemispheric Repetitive Transcranial Magnetic Stimulation for Upper Limb Motor Recovery in Chronic Stroke: A Feasibility Study

Deep Repetitive Transcranial Magnetic Stimulation with H-coil on Lower Limb Motorfunction after Stroke: a Pilot Study

Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue

Benefits of Deep Transcranial Magnetic Stimulationin Alzheimer Disease: Case Series

Enhanced cognition and emotional recognition, and reduced obsessive compulsive symptoms in two adults with high-functioning autism as a result of deep Transcranial Magnetic Stimulation (dTMS): a case report

A Double-blind, Randomized Trial of Deep Repetitive Transcranial Magnetic Stimulation (rTMS) for Autism Spectrum Disorder

Deep Repetitive Transcranial Magnetic Stimulation Associated with Improved Social Functioning in a Young Woman withan Autism Spectrum Disorder

Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome / interstitial cystitis

Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine: A preliminary study

Deep TMS Augmentation Treatment for Fibromyalgia: A Safety and Feasibility Study

H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy

Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil

Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

Insular and anterior cingulate cortex deep stimulation for central neuropathic pain

Right Prefrontal Deep Tms Effects on Attention Symptoms: Behavioral Outcomes and Electrophysiological Correlates

Right Prefrontal Transcranial Magnetic Stimulation for Adults with ADHD: Electrophysiological Correlates and Prognostic Biomarkers

Deep Transcranial Magnetic Stimulation Over the Right Prefrontal Cortex Improves ADHD Symptoms: A Combined TMS-EEG Study

Randomised Sham-Controlled Study of High-Frequency Bilateral Deep Transcranial Magnetic Stimulation (dTMS) to Treat Adult Attention Hyperactive Disorder (ADHD): Negative Results

Effects of Repetitive Transcranial Magnetic Stimulation over Prefrontal Cortex on Attention in Psychiatric Disorders: A Systematic Review

Clinical and electrophysiological effects of two dTMS protocols in ADHD

Retrospective evaluation of deep transcranial magnetic stimulation as add-on treatment for Parkinson’s disease

Excitatory Deep Repetitive Transcranial Magnetic Stimulation with H-coil as Add-on Treatment of Motor Symptoms in Parkinson’s Disease: An Open Label, Pilot Study

Repetitive deep transcranial magnetic stimulation for Motor symptoms in Parkinson’s disease: A feasibility study

Deep rTMS for Neuropsychiatric Symptoms of Huntington’sDisease: Case Report

Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue

H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

Bi-hemispheric Repetitive Transcranial Magnetic Stimulation for Upper Limb Motor Recovery in Chronic Stroke: A Feasibility Study

Deep Repetitive Transcranial Magnetic Stimulation with H-coil on Lower Limb Motorfunction after Stroke: a Pilot Study

Chieffo, R., De Prezzo, S., Houdayer, E., Nuara, A., Di Maggio, G., Coppi, E., & Leocani, L. (2014). Archives of physical medicine and rehabilitation.

Repetitive Deep Transcranial Magnetic Stimulation Improves Verbal Fluency and Written Language in a Patient with Primary Progressive Aphasia-Logopenic Variant (LPPA)

Excitatory Deep Transcranial Magnetic Stimulation with H-Coil Over the Right Homologous Broca’s Region Improves Naming in Chronic Post-Stroke Aphasia

Clinical and Electrophysiological Outcomes of deep TMS Over the Medial Prefrontal and Anterior Cingulate Cortices in OCD Patients

Deep Transcranial Magnetic Stimulation of the Anterior Cingulate Cortex in Obsessive Compulsive Disorder Patients

Efficacy and Safety of Deep Transcranial MagneticStimulation for Obsessive-Compulsive Disorder:A Prospective Multicenter RandomizedDouble-Blind Placebo-Controlled Trial

The BrainsWay Advantage for Treatment Resistant Depression Patients

Retrospective evaluation of deep transcranial magnetic stimulation as add-on treatment for Parkinson’s disease

Excitatory Deep Repetitive Transcranial Magnetic Stimulation with H-coil as Add-on Treatment of Motor Symptoms in Parkinson’s Disease: An Open Label, Pilot Study

Repetitive deep transcranial magnetic stimulation for Motor symptoms in Parkinson’s disease: A feasibility study

Does BrainsWay Deep TMS treatment entail any side effects or risks?

How does BrainsWay Deep TMS treatment compare with ECT?

What are the chances of improvement using BrainsWay Deep TMS Therapy?

What are the CE indications for BrainsWay Deep TMS?

What do patients usually feel during BrainsWay Deep TMS treatment sessions?

Has BrainsWay Deep TMS therapy been tested?

Does BrainsWay’s Deep TMS Therapy have any side effects?

Does Deep TMS treatment entail any discomfort?

What is TMS Psychiatry and what are the advantages?

How much does TMS therapy cost?

Where can I go to get Deep TMS treatment?

Is Deep TMS covered by insurance?

What happens during a Deep TMS procedure?

What is Deep TMS and how does it work?

Will I need to stop my medication or therapy?

How long does Deep TMS treatment take?

Who is eligible for Deep TMS treatment?

Are there any safety concerns or side effects related to Deep TMS therapy?

What evidence exists for Deep TMS effectiveness?

Effectiveness of Deep Transcranial Magnetic Stimulation Combined with a Brief Exposure Procedure in Post-Traumatic Stress Disorder-A Pilot Study

Repetitive transcranial magnetic stimulation in trauma-related conditions

Has BrainsWay’s Deep TMS therapy been tested?

Who is eligible for BrainsWay Deep TMS therapy?

What are the CE indications for BrainsWay Deep TMS?

What are the chances of improvement using BrainsWay Deep TMS Therapy?

Does BrainsWay’s TMS treatment entail any side effects or risks?

Who is authorized to administer Deep TMS treatment?

Is Deep TMS covered by insurers?

How does BrainsWay Deep TMS treatment work?

How does Deep TMS compare to standard rTMS?

What payment options does BrainsWay offer partners to cover Deep TMS system costs?

Are there any safety concerns or side effects from the treatment?

What clinical evidence exists for Deep TMS efficacy?

What support does BrainsWay provide Deep TMS operators?

Who is likely to benefit from Deep TMS?

Does Deep TMS require any special equipment or facilities?

What mental health conditions is Deep TMS FDA-cleared to treat?

Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study

Deep TMS on Alcoholics: Effects on Cortisolemia and Dopamine Pathway Modulation. A Pilot Study

Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial

How Deep is the Deep Transcranial Magnetic Stimulation (dTMS)? Putative Stimulation of Reward Pathways in Substanceuse Disorders: A Systematic Review and Meta-Analysis

Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: A systematic review and meta-analysis

A Review of Brain Stimulation Methods to Treat SubstanceUse Disorders

Transcranial Magnetic Stimulation (TMS) in the Elderly

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

High Frequency Deep TMS over the Bilateral Insula is Associated with Increased Degree Centrality in the Prefrontal Cortex of Obese Subjects: Preliminary Evidence

Deep Transcranial Magnetic Stimulation Acutely ModulatesNeuro-EndocrinePathwaysUnderlyingObesity

Deep Transcranial Magnetic Stimulation Attenuates Depressive and Anxiety Symptoms Associated with Obesity

Effects of Deep Transcranial Magnetic Stimulation (dTMS) on Anti-inflammatory Gut Bacterial Species in Obesity

Can deep transcranial magnetic stimulation (dTMS) be used to treat substance use disorders (SUD)? A systematic review

Deep Transcranial Magnetic Stimulation Over the Medial Prefrontal and Anterior Cingulate Cortex Alters Brain Connectivity and Reduces Relapses to Alcohol Use

Sequential l-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst DTMS For Highly-Suicidal Treatment-Resistant Depression Patients

H1-coil Intermittent Theta Burst Stimulation For a Patient With a High Motor Threshold: Case Report

Alternative Antidepressant Deep Transcranial Magnetic Stimulation Protocols

H-Coil Intermittent Theta Burst Stimulation for a Patient with a High Motor Threshold: Case Report

Sequential L-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst dTMS for Suicidal Highly Treatment Resistant Depression Patients

Bersani, F. S., Girardi, N., Sanna, L., Mazzarini, L., Santucci, C., Kotzalidis, G. D., & Girardi, P. (2013). Neurocase, 19(5), 451-457.

H-coil repetitive transcranial magnetic stimulation for the treatment of bipolar depression: an add-on, safety and feasibility study

Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression

Deep Transcranial Magnetic Stimulation for treatment-resistant bipolar disorder: A case report of acute and maintenance efficacy

Treatment of Bipolar Disorder with Deep TMS: Results from a Double-Blind, Randomized, Parallel Group, Sham-ControlledClinicalTrial

Cognitive outcomes of TMS treatment in bipolar depression: Safety data from a randomized controlled trial

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex in depressive episodes of patients with Major Depressive Disorder, Bipolar Disorder I, and Major Depressive with Alcohol Use Disorders

Levkovitz, Y., Rabany, L., Harel, E. V., & Zangen, A. (2011). The International Journal of Neuropsychopharmacology, 14(07), 991-996.

Rosenberg, O., Roth, Y., Kotler, M., Zangen, A., & Dannon, P. (2011). Annals of general psychiatry, 10(1), 3.

Deep transcranial magnetic stimulationadd-on for treatment of negative symptomsand cognitive deficits of schizophrenia:a feasibility study

Double-blind, randomized sham controlled study of deep-TMS add-on treatment for negative symptoms and cognitive deficits in schizophrenia

Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: adouble-blind study

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: apreliminary open-label study

Deep Transcranial Magnetic Stimulation for the Treatment of negative Symptoms in Schizophrenia: Beyond an Antidepressant Effect

Effectiveness of Deep Transcranial Magnetic Stimulation Combined with a Brief Exposure Procedure in Post-Traumatic Stress Disorder-A Pilot Study

Repetitive transcranial magnetic stimulation in trauma-related conditions

Deep-TMS Add-On Treatment for Intractable Tourette syndrome: A Feasibility Study

dmPFC-ACC dTMS for Refractory Body Dysmorphic Disorder: Case Report

Personality traits and antidepressant effects of deep repetitive transcranial magnetic stimulation (dTMS)

Levkovitz, Y., Harel, E. V., Roth, Y., Braw, Y., Most, D., Katz, L. N., & Zangen, A. (2009). Brain Stimulation, 2(4), 188-200.

Levkovitz, Y., Roth, Y., Harel, E. V., Braw, Y., Sheer, A., & Zangen, A. (2007). Clinical Neurophysiology, 118(12), 2730-2744.

Alternate Day dTMS Combined with SSRIs for Chronic Treatment Resistant Depression: A Prospective Multicenter Study

Simultaneous Aerobic Exercise and rTMS: Feasibility of Combining Therapeutic Modalities to Treat Depression

Add-On High Frequency Deep Transcranial Magnetic Stimulation (dTMS) to Bilateral Prefrontal Cortex in Depressive Episodes of Patients With Major Depressive Disorder, Bipolar Disorder, and Major Depressive with Alcohol Use Disorders

Effectiveness of a Second Deep TMS in Depression: A Brief Report

Acute Reduction in Anxiety After Deep Transcranial Magnetic Stimulation (DTMS) in Unipolar Major Depression-a Systematic Review and Meta-Analysis

Background:

Objective:

To report the effects of a 4-week trial of dTMS on depressive and anxious symptoms as well as on brain activity in an adult patient with TRD.

Methods:

Results:

Conclusions:

Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Late-Life Depression: a Prospective Randomized Controlled Trial

Deep TMS in a Resistant Major Depressive Disorder: a Brief Report

Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex: Evaluation of Antidepressant and Cognitive Effects in Depressive Patients

Deep Transcranial Magnetic Stimulation (DTMS) in the Treatment of Major Depression: An Exploratory Systematic Review and Meta-analysis

Differential Effects of Deep TMS of the Prefrontal Cortex on Apathy and Depression

Augmenting Antidepressants With Deep Transcranial Magnetic Stimulation (dTMS) in Treatment-Resistant Major Depression

Personality Dimensions and Deep Repetitive Transcranial Magnetic Stimulation (dTMS) for Treatment-Resistant Depression: A Pilot Trial on Five-Factor Prediction of Antidepressant Response

Cognitive-Emotional Reactivation During Deep Transcranial Magnetic Stimulation Over the Prefrontal Cortex of Depressive Patients Affects Anti Depressant Outcome

Antidepressant Effectiveness of Deep Transcranial Magnetic Stimulation (dTMS) in Patients with Major Depressive Disorder (MDD) With or Without Alcohol Use Disorders (AUDs): A 6-Month, Open Label, Follow-up Study

Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Clinically-Relevant Outcomes of Deep Transcranial Magnetic Stimulation (dTMS) in Unipolar Major Depression: A Systematic Review and Meta-Analysis

Response to Deep TMS in Depressive Patients with Previous Electroconvulsive Treatment

H-coil Repetitive Transcranial Magnetic Stimulation for Treatment Resistant Major Depressive Disorder: An 18-week Continuation Safety and Feasibility Study

61% of Unmedicated Treatment Resistant Depression Patients Who Did Not Respond to Acute TMS Treatment Responded After Four Weeks of Twice Weekly deep TMS in the BrainsWay Pivotal Trial

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Major Depression: a Prospective Multicenter Randomized Controlled Trial

Potential Predictors of Depressive Relapse Following Repetitive Transcranial Magnetic Stimulation: A Systematic Review

Durability of antidepressant response to repetitive transcranial magnetic stimulation: systematic review and meta-analysis

Application of transcranial magnetic stimulation for major depression: Coil design and neuroanatomical variability considerations

Personality traits and antidepressant effects of deep repetitive transcranial magnetic stimulation (dTMS)

Alternative antidepressant deep transcranial magnetic stimulation protocols

What Intensity of Deep Transcranial Magnetic Stimulation is Necessary to Remit Treatment Resistant Depression

Antidepressant outcomes of highfrequency repetitive transcranial magnetic stimulation (rTMS) with F8-coil and deep transcranial magnetic stimulation (dTMS) with H1-coil in major depression: a systematic review and meta-analysis

A Novel Dual-Channel Deep Transcranial Magnetic Stimulator for Major Depressive Disorder

Clinical and Electrophysiological Outcomes of deep TMS Over the Medial Prefrontal and Anterior Cingulate Cortices in OCD Patients

Deep Transcranial Magnetic Stimulation of the Anterior Cingulate Cortex in Obsessive Compulsive Disorder Patients

Efficacy and Safety of Deep Transcranial MagneticStimulation for Obsessive-Compulsive Disorder:A Prospective Multicenter RandomizedDouble-Blind Placebo-Controlled Trial

Girardi P1, Rapinesi C, Chiarotti F, Kotzalidis GD, Piacentino D, Serata D, Del Casale A, Scatena P, Mascioli F, Raccah RN, Brugnoli R, Digiacomantonio V,Ferri VR, Ferracuti S, Zangen A, Angeletti G. World J Biol Psychiatry. 2014 Aug 20:1-8.

The study compared standard drug treatment (n=10) with drug treatment combined with Brainsway® Deep TMS (Transcranial Magnetic Stimulation ; n=10) for treating mood and substance use disorders through stimulation of the Dorsolateral prefrontal cortex (DLPFC). The study, held over 6 months, included abstinent patients suffering from Alcohol Use Disorder, who also had a previous dysthymic disorder. The study showed that after 20 sessions of Deep TMS, craving and depressive symptoms dropped significantly, suggesting that Brainsway’s Deep TMS is well tolerated and effective as an add-on treatment for alcohol use disorder.

Rapinesi C1, Kotzalidis GD, Scatena P, Del Casale A, Janiri D, Callovini G, Piacentino D, Serata D, Raccah RN, Brugnoli R, Digiacomantonio V, Mascioli F,Ferri VR, Ferracuti S, Pompili M, De Pisa E, Di Pietro S, Zangen A, Angeletti G, Girardi P., Psychiatr Danub. 2014 Sep;26(3):281-4.

A 56-year-old man experienced anxiety, depression, sexual dysfunction, suicidal thoughts and alcohol intake of up to 1.5 liters a day. In this case study, the patient received 20 sessions of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) over a period of a month. After the 7th session, anxiety, panic-like symptoms and craving for drinking disappeared. After the 11th session, suicidal thoughts decreased, and after the final session the patient showed various improvements, including increased libido and decreased depressive symptoms. At the 6-month follow-up, he did not resume drinking, had no craving for alcohol and no suicidal thoughts.

Girardi P1, Rapinesi C, Chiarotti F, Kotzalidis GD, Piacentino D, Serata D, Del Casale A, Scatena P, Mascioli F, Raccah RN, Brugnoli R, Digiacomantonio V,Ferri VR, Ferracuti S, Zangen A, Angeletti G. World J Biol Psychiatry. 2014 Aug 20:1-8.

Bipolar Disorder – Double-Blind Placebo Control Safety and Feasibility Study

Shalvata Mental Health Center, Hod-Hasharon, Israel

13 January, 2009

A double-blinded and placebo-controlled clinical trial has begun at the Shalvata Mental Health Center to explore the efficacy and safety of Braisnway® Deep TMS in 50 subjects with bipolar depression, currently treated with mood stabilizers and previously unsuccessfully treated with antidepressant medication.

The trial is expected to be carried out over the course of 7 weeks in respect of each subject.

This trial is expected to serve as the basis for a broad multi-center trial.

Bloch, Y., Arad, S., & Levkovitz, Y. (2014). World Journal of Biological Psychiatry, (Epub ahead of print).

This study explores the effect of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) on adults who suffer from intractable Tourette Syndrome (TS). The study enrolled 12 patients and was held over 20 days. The study found no significant side effects, and indicated that Deep TMS is safe for treating TS. In the study, the subgroup who suffered from both TS and Obsessive Compulsive Disorder (OCD) experienced significant improvement – a beneficial result that also indicates that TS is not of a uniform nature.

Isserles, M., Rosenberg, O., Dannon, P., Levkovitz, Y., Kotler, M., Deutsch, F., & Zangen, A. (2011). Journal of affective disorders, 128(3), 235-242.

This study examined the effect of the Transcranial Magnetic Stimulation H-coil on patients suffering from depression, following positive or negative emotional triggering. This was done by focusing the patients on either positive or negative thoughts or emotions associated with the patient’s depression. In this study, it was demonstrated that positive, rather than negative, emotional triggering prior to brain stimulation using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil results in more favorable treatment outcomes.

Roth, Y., Zangen, A., & Hallett, M. (2002). Journal of Clinical Neurophysiology, 19(4), 361-370.

This paper introduces, for the first time, the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil. The paper illustrates the considerations relevant to the design of the coil and compares the H-coil to a standard coil using a model of the human head. The study demonstrates that the electric field generated by the H-coil decays at a much slower pace than the electric field generated by the standard coil, indicating the H-Coil’s deeper penetration of the brain.

Cooperation with Institutions for Deep Transcranial Magnetic Stimulation

Brainsway® runs clinical research programs with leading scientists worldwide, collaborating with prominent institutions and researchers in clinical trials covering various neuropsychiatric and neuroscience applications for deep transcranial magnetic stimulation.

Enticott, P. G., Kennedy, H. A., Zangen, A., & Fitzgerald, P. B. (2011). The journal of ECT, 27(1), 41-43.

This case report examines the effect of Brainsway® Deep TMS (transcranial magnetic stimulation) in a patient with autism. In the case report, high-frequency stimulation was administered for 15 minutes per session, 9 treatments over 11 days. In this patient, social and interpersonal communications abilities were improved following treatment, as noted both by the patient and by her family. The conclusions were that Deep Transcranial Magnetic Stimulation in ASD can improves several facets of cortical dysfunction.

Barr, M. S., & George, T. P. (2014). Biological Psychiatry, 1;76(9):678-80.

This report describes a double-blind, sham-controlled trial that used the Brainsway Deep TMS (Transcranial Magnetic Stimulation) H-Coil for smoking cessation. It was found that, when applied bilaterally on the dorsolateral prefrontal cortex (DLPFC) and insular cortex, the H-coil may decrease short-term biochemically verified smoking and nicotine dependence levels and increase short- and long-term smoking abstinence rates.

Hadassah Ein-Kerem Medical Center, Jerusalem, and Be'er Ya'akov Mental Health Center, Israel

6 August 2009

clinical trial of studying the feasibility of using the Deep TMS H System in augmentation of antidepressant drugs, for the treatment of resistant depression, took place at the Hadassah Ein-Kerem Medical Center, Jerusalem, and Be’er Ya’akov Mental Health Center, Israel.

Results demonstrate a substantial therapeutic advantage for deep and widespread stimulation using Brainsway’s proprietary ADHD coil over superficial stimulation with a standard figure-8 coil

Brainsway® Ltd. (TASE: BRIN), a leader in non-invasive brain stimulation, is pleased to announce final results from a phase II clinical study investigating the efficacy of Deep transcranial magnetic stimulation (Deep TMS) using a specialized electromagnetic coil developed for the treatment of attention deficit hyperactivity disorder (ADHD) in adults. The study was conducted at the Soroka University Medical Center in Beer Sheva, Israel, in collaboration with the Ben Gurion University, and was led by Principal Investigators Dr. Hadar Shalev and Prof. Abraham Zangen.

Rosenberg, O., Shoenfeld, N., Zangen, A., Kotler, M., & Dannon, P. N. (2010). Depression and anxiety, 27(5), 465-469.

his study examined the effect of the Brainsway® Deep Transcranial Magnetic Stimulation H-coil as an add-on treatment for patients suffering from drug-resistant depression. The study comprised depression patients, and treated them with Brainsway Deep Transcranial Magnetic Stimulation H1-coil, which was connected to a Magstim rapid 2 stimulator. In the study, the average HDRS and average Hamilton Anxiety Rating Scale score decreased. In this study it was demonstrated that using Deep TMS as an add-on treatment results in significant alleviation of symptoms.

Deep TMS Treatment for Bipolar Disorder

Shalvata Medical Health Center, Hod-Hasharon, Israel

2 October 2008

A clinical trial of studying the feasibility of using the Deep TMS H System for treating bi-polar disorder episodes, took place at the Shalvata Mental Health Center, Hod-Hasharon, Israel.

Brainsway Ltd. announces the final results of a clinical trial utilizing the Company’s Deep TMS device for the treatment of Bipolar Depression (Manic Depression) in subjects that did not respond to medication, as such results was presented in a conference on the matter that was held in Germany. The trial was performed in Shalvata hospital in the framework of a collaborative effort between the Company and the hospital, and its objective was to investigate treatment utilizing the Company’s Deep TMS device.

Shalvata Mental Health Center, Hod-Hasharon, Israel

10 March 2008

A clinical trial using the Deep TMS H System to treat schizophrenic patients, began in August 2006 at the Shalvata Mental Health Center, Hod-Hasharon, Israel.

In a recent ongoing open trial, feasibility safety and efficacy of the H1 coil in the treatment of negative symptoms and cognitive deficits is studied at the Shalvata Mental Health Center.

Kedzior, K. K., Gellersen, H. M., Brachetti, A. K., & Berlim, M. T. (2015). Journal of Affective Disorders, 187:73–83

This review and meta-analysis paper concerns the acute effect of Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) on major depressive disorder (MDD). The review included 9 open label studies enrolling mostly treatment resistant MDD patients. Analysis was conducted for the treatment’s effect, based on the accepted depression rating scale (HDRS), and the rate of responders, patients that achieved remission, and patients that did not complete the experiment (dropouts).

The study found that high-frequency stimulation over 20 sessions led to a significant alleviation of the depressed state in the majority of patients; and it was suggested that employing Deep TMS as an add-on to concurrent medication may increase the effectiveness of both treatments.

Bersani, F. S., Minichino, A., Enticott, P. G., Mazzarini, L., Khan, N., Antonacci, G., & Biondi, M. (2013). European Psychiatry, 28(1), 30-39.

This paper reviews the work done so far using the Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) H-coil, and demonstrates the biological and physical components that participate in the effects generated by Deep Transcranial Magnetic Stimulation; both in general terms and for specific psychiatry disorders.

Be'er Ya'akov Mental Health Center, Be'er Ya'akov, Israel

3 January 2010

Brainsway is pleased to announce its final results from a clinical trial of the Company’s Deep TMS device for the treatment of auditory hallucinations in schizophrenic patients. The trial was performed at the Be’er Ya’akov Mental Health Center in the framework of a collaboration between Brainsway, the Be’er Ya’akov Mental Health Center and the Medical Research Fund of the Assaf Harofeh Hospital.

Levkovitz, Y., Sheer, A., Harel, E. V., Katz, L. N., Most, D., Zangen, A., & Isserles, M. (2011). Brain stimulation, 4(4), 266-274.

This study examined the effect of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on depressed patients, and evaluated separately the effect on depressive symptoms and on one of depression’s core symptoms – apathy. In the study, antidepressant medication treatment was ceased, and Deep Transcranial Magnetic stimulation was given 5 days a week, over 4 weeks. The study demonstrated that brain stimulation using the Deep TMS H-coil significantly alleviates depressive symptoms including apathy, but only if pre-treatment apathy was not very severe

Shalvata Mental Health Center, Israel

6 March 2013

The purpose of the study is to explore the efficacy and safety of HBLPADD Coil Deep TMS in subjects with ADHD. The Patient Population is 40 patients diagnosed with ADHD. The patients will be of all racial, ethnic and gender categories, ranging from 18 to 65 years of age.

Rabany, L., Deutsch, L., & Levkovitz, Y. (2014). Journal of Psychopharmacology, 4;28(7):686-690.

The study examined Brainsway® Deep TMS (Transcranial Magnetic Stimulation) as an add-on treatment for negative symptoms and cognitive deficits in schizophrenia. In the study, 30 patients were randomly assigned to receive real or sham Deep TMS (20 sessions), where both patients and operators were not aware of the type of treatment. In the study, negative symptoms significantly decreased in the group that received real Deep TMS treatment.

Sapienza University of Rome, Italy

26 June, 2011

Further to that stated in Brainsway®’s periodic report for 2010 regarding the double-blinded clinical trial for the treatment of diabetic chronic neuropathic pain that was conducted by Advanced Technologies Innovation Distribution SRL (“Atid”) in Italy using the Company’s Deep TMS device, the Company is pleased to announce the final results of the trial, which was performed on 33 subjects, with each subject receiving a series of REAL treatments over five days, and a series of SHAM treatments over five days. The time gap between these series was 45 days, and the order of REAL and SHAM treatments was randomized.

National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, USA

24 October, 2010

Further to that stated in Brainsway®’s periodic report for 2009, the Company is pleased to announce that analysis of the results of the clinical trial of the Company’s Deep TMS device for the treatment of the symptoms of blepharospasm (a disorder that affects the eye muscles and causes uncontrolled blinking), reveals that low-frequency Deep TMS treatment using the specialized H-BL TMS coil developed by the Company or using a C-coil (a coil employed in TMS studies), is safe and it leads to immediate alleviation of blepharospasm symptoms. The trial followed a double-blind design with a control group, and was performed by researchers from the National Institute of Neurological Disorders and Stroke (NINDS) research division of the NIH, headed by Dr. Mark Hallett.

sserles, M., Shalev, A. Y., Roth, Y., Peri, T., Kutz, I., Zlotnick, E., & Zangen, A. (2013). Brain stimulation, 6(3), 377-383.

This study examined the effect of Brainsway® Deep TMS (Transcranial Magnetic Stimulation) on PTSD patients, following activation of the traumatic memory. In this double-blind study, patients who received real stimulation showed substantial improvement in the intrusive component of the CAPS scale, after exposure to the traumatic event script. The study demonstrated that the H-coil significantly alleviated PTSD symptoms following memory activation, but not following non-provoked or sham stimulations.

Rosenberg, O., Isserles, M., Levkovitz, Y., Kotler, M., Zangen, A., & Dannon, P. N. (2011). Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(4), 1041-1044.

This study examined the effect of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on depressed patients which previously benefited from the treatment but suffered from deterioration. The patients were given 20 daily sessions of stimulation, resulting in a significant decrease in HDRS, HARS and BDI scores, although at a lesser rate compared to the decrease during the first Deep TMS treatment period. In this study it was demonstrated that a second treatment period of brain stimulation using the H-coil significantly alleviates depressive symptoms.

Shalvata Mental Health Center, Israel

11 March 2012

The purpose of this study is to evaluate the safety and anti-depressive response of the H1 Coil TMS Device in elderly patients suffering from major depressive episode.

Chieffo, R., Ferrari, F., Battista, P., Houdayer, E., Nuara, A., Alemanno, F., & Leocani, L. (2013). Neurorehabilitation and neural repair, 1545968313508471.

This study was designed to examine the effect of different stimulation frequencies on the inability to use spoken language due to a stroke-induced brain lesion. Patients were tested for their ability to correctly name a picture following either high, low, or sham stimulation. This study demonstrated that acute, high-frequency, brain stimulation using Brainsway® Deep TMS, or Deep Transcranial Magnetic Stimulation, significantly improves stroke-induced inability to use spoken language.

Onesti, E., Gabriele, M., Cambieri, C., Ceccanti, M., Raccah, R., Di Stefano, G., & Inghilleri, M. (2013). European Journal of Pain, 17(9), 1347-1356.

The study examined the effect of stimulation on pain sensation and joint bending reflex in patients with diabetic-induced pain. During two one-week treatment periods, separated by 5 weeks, patients received either real or sham stimulation. In this study it was demonstrated that brain stimulation using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil, but not sham stimulation, significantly improved results in both measurements. Moreover, these beneficial effects were still present in the 3 week follow-up session.

Harel, E. V., Zangen, A., Roth, Y., Reti, I., Braw, Y., & Levkovitz, Y. (2011). World Journal of Biological Psychiatry, 12(2), 119-126.

This study examined the effect of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil as an add-on treatment for patients suffering from bipolar depression. In the study, bipolar depression patients who were under medication treatment received daily rTMS for four consecutive weeks. The study demonstrated that adding brain stimulation using the Brainsway Deep TMS H-coil results in significant alleviation of symptoms.

Harel, E. V., Rabany, L., Deutsch, L., Bloch, Y., Zangen, A., & Levkovitz, Y. (2014). The World Journal of Biological Psychiatry, 15(4), 298-306.

This study examined the long-term effect of Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) on depressed patients. Patients underwent 4 weeks of intensive treatment and 18 weeks of maintenance treatments. The study demonstrated that brain stimulation using Brainsway’s Deep Transcranial Magnetic Stimulation significantly alleviates depressive symptoms, and that this beneficial effect can be maintained for a long period of time.

Shalvata Mental Health Center, Hod Hasharon, Israel

Further to Brainsway’s periodic report for 2009 regarding the maintenance treatment clinical trial performed by the Company on patients who responded to the previous clinical trial of the Deep TMS device for acute treatment of drug-resistant major depression, the Company is pleased to announce that final results in respect of 30 patients have been obtained.

22 medical centers in the USA, Canada, Europe and Israel

16 September, 2009

A multicenter clinical trial for the assessment of the efficacy and safety of Brainsway® Deep TMS in subjects suffering from major depression disorder (MDD) took place in 22 medical centers in the USA, Canada, Europe and Israel.

The purpose of the study was to evaluate the efficacy and safety of Brainsway Deep TMS, in subjects suffering from Major Depressive Disorder who have been unsuccessfully treated with antidepressant medication.

The study, which took place over 16-weeks, is a Double-Blind Placebo-Controlled study which enrolled over 230 subjects. The results showed a profound decline in HDRS-21 and significant remission (32.6%) and response (38.4%) rates at the primary endpoint of the study. Brainsway treatment was proved to be safe, as the treatment was well tolerated by the majority of the study subjects.

Following this study, the FDA* granted Brainsway a wide indication for the treatment of Depression patients who did not benefit from any number of previous medication treatments.

* FDA 510(k) No. K122288

Charité University, Berlin, Germany; University Medical Center Hamburg-Eppendorf, Hamburg, Germany

21 March, 2010

A clinical trial of Brainsway®’s Deep TMS for the treatment of multiple sclerosis patients (MS) has begun in two leading medical centers in Germany: the Charité Hospital – considered to be the leading university hospital in Berlin, and the University Medical Center Hamburg-Eppendorf, in Hamburg.

Torres F, Villalon E, Poblete P, Moraga-Amaro R, Linsambarth S, Riquelme R, Zangen A. and Stehberg J. Retrospective Evaluation of Deep Transcranial Magnetic Stimulation as Add-On Treatment for Parkinson’s Disease. Front Neurol. 2015; 6: 210.

The study examined the effectiveness of Brainsway® Deep TMS as an add-on treatment for Parkinson’s patients who are regularly treated with medication but show insufficient response to the standard medications. The study included 45 Parkinson’s patients, who underwent 14 sessions of Brainsway Deep TMS treatment over three weeks. Each treatment session included low-frequency stimulation (1 Hz) of the motor cortex (M1) for 15 minutes, immediately followed by high-frequency stimulation (10 Hz) of the lateral prefrontal cortex for an additional 15 minutes.

The researchers’ conclusion is that the Deep TMS system with the unique coil that was developed for Parkinson’s disease is safe and effective for use as an add-on treatment for Parkinson’s patients. Additionally, the researchers concluded that Deep TMS can affect a wider range of symptoms than those previously reported in professional literature regarding the impact of treatment, based on standard TMS coils that generate only superficial stimulation (manufactured by a competing provider).

Trebbastoni, A., Raccah, R., de Lena, C., Zangen, A., & Inghilleri, M. (2013). Brain stimulation, 6(4), 545-553.

This case report examines the effect of Brainsway Deep TMS (Transcranial Magnetic Stimulation) in a patient that had a language disorder involving changes in the ability to speak, read, write and understand what others are saying. The patient underwent four 20-minute stimulation cycles, including two real sessions and two sham sessions, over five consecutive days. In this patient, both the ability to speak and to write were significantly enhanced following one week of deep brain stimulation, but not following sham stimulation.

National Institutes of Health (NIH), Bethesda, Maryland, USA

18 April, 2005

The first clinical study, Zangen et al. (2005), performed at the National Institute of Health (NIH) tested the efficacy and safety aspects of the H-coil on healthy volunteers.

The H-coil was compared to a regular figure-8 coil in 6 healthy volunteers by measuring thresholds for activation of the abductor pollicis brevis (APB) representation in the motor cortex as a function of distance from each of the coils. The findings of this study indicated that the rate of decrease in the coil intensity as a function of distance is markedly slower for the H-coil.

Shalvata Medical Health Center, Hod-Hasharon, Israel

14 February, 2008

This study evaluated the safety and feasibility of H- coil rTMS in the treatment of patients suffering from treatment-resistant MDD at the Shalvata Mental Health Center, Tel Aviv University, Israel. The study begun in 2006 and was completed in the beginning of 2008.

Shalvata Medical Health Center, Hod-Hasharon, Israel

1 January, 2006

A second safety study was conducted in Shalvata Mental-Health Center, Hod HaSharon, Israel in 2005 (Zangen et al., 2006).

The study assessed any possible health risks, as well as cognitive and emotional transient effects of the novel design of Brainsway® Deep TMS H-Coils.

Comparing treatments conducted with H1-coil, H2-coil, Standard figure-8 coil (Quadstim; manufactured by MagStim) and Sham coil. The treatment groups (H1-coil TMS, H2-coil TMS, figure-8 coil TMS & sham TMS) did not differ in age, years of education and sex.

Shalvata Mental Health Center, Hod Hasharon, Israel

9 March, 2009

A double-blind placebo-controlled clinical trial utilizing the Brainsway®’s Deep TMS device for the treatment of negative symptoms in 45 patients with schizophrenia has begun at the Shalvata Mental Health Center.

The trial began on March 2009, and is expected to be carried out over the course of 7 weeks in respect of each subject.

This trial is expected to serve as the basis for a broad multi-center trial.

Shimizu et al. Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil

A recent study performed in Japan compared the safety and efficacy of a Brainsway deep TMS H-coil, a standard figure-8 TMS coil and a sham coil (placebo) for the treatment of 18 patients suffering from neuropathic pain. All patients received all three types of treatment in a crossover design. It was found that only the deep TMS H-coil induced significant pain improvements, while the results of the figure-8 were not significantly different than the sham. The treatment was well tolerated and no serious adverse events were reported.

Be'er Ya'akov Mental Health Center, Israel

1 July, 2009

A clinical trial in Chronic Obstructive Pulmonary Disease Patients with an Addiction to Smoking, has begun at the Mental Health Center in Be’er Ya’akov, Israel.

The study aim is to assess the efficacy of Brainsway® Deep TMS device in inducing smoking cessation in chronic obstructive pulmonary disease patients. Between 90 and 120 patients are expected to participate in the trial. The trial will be a blinded placebo-controlled study.

Roth, Y., Amir, A., Levkovitz, Y., & Zangen, A. (2007). Journal of Clinical Neurophysiology, 24(1), 31-38.

This study compares the penetration depths of two different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and a standard coil (Figure 8 coil). In the study, electrical fields of H-coils and of a Figure 8 coil were measured using a head model. This study demonstrates that the H-coil is able to reach significantly deeper brain areas than those reached by the figure-of-8 coil. Also, it was shown that the H-coils allow for stimulation of several brain regions at the same time.

Kranz, G., Shamim, E. A., Lin, P. T., Kranz, G. S., & Hallett, M. (2010). Neurology, 75(16), 1465-1471.

This study examined the effect of both the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil and circular-coil stimulation on patients suffering from abnormal blinking or spasms of the eyelids. In the study, patients underwent a 15-minute session of repetitive transcranial magnetic stimulation over the ACC. In this study it was demonstrated that although both type of coils were effective compare to a sham coil, and significantly alleviate symptoms, acute brain stimulation using the H-coil required a significantly lower stimulation intensity.

Zangen, A., Roth, Y., Voller, B., & Hallett, M. (2005). Clinical neurophysiology, 116(4), 775-779

This study compares the penetration depths of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil to a standard coil (figure 8) in healthy individuals. The study tested the efficacy, and some issues related to safety, of the H-coil, on healthy volunteers. In this study it was demonstrated that the H-coil is able to reach significantly deeper brain areas than those reached by the figure-of-8 coil. Moreover, the stimulation is achieved without increasing the intensity to extreme levels.

Roth, Y., Padberg, F., & Zangen, A. (2007). In “Transcranial Brain Stimulation for Treatment of Psychiatric Disorders” (Vol. 23).

This book chapter describes the biological and physical components that participate in the effects of Brainsway®’s Deep TMS (Transcranial Magnetic Stimulation) H-Coil for brain stimulation.

Levkovitz, Y., Rabany, L., Harel, E. V., & Zangen, A. (2011). The International Journal of Neuropsychopharmacology, 14(07), 991-996.

Rosenberg, O., Roth, Y., Kotler, M., Zangen, A., & Dannon, P. (2011). Annals of general psychiatry, 10(1), 3.

Deep transcranial magnetic stimulationadd-on for treatment of negative symptomsand cognitive deficits of schizophrenia:a feasibility study

Double-blind, randomized sham controlled study of deep-TMS add-on treatment for negative symptoms and cognitive deficits in schizophrenia

Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: adouble-blind study

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: apreliminary open-label study

Deep Transcranial Magnetic Stimulation for the Treatment of negative Symptoms in Schizophrenia: Beyond an Antidepressant Effect

Bi-hemispheric Repetitive Transcranial Magnetic Stimulation for Upper Limb Motor Recovery in Chronic Stroke: A Feasibility Study

Deep Repetitive Transcranial Magnetic Stimulation with H-coil on Lower Limb Motorfunction after Stroke: a Pilot Study

Chieffo, R., De Prezzo, S., Houdayer, E., Nuara, A., Di Maggio, G., Coppi, E., & Leocani, L. (2014). Archives of physical medicine and rehabilitation.

Repetitive Deep Transcranial Magnetic Stimulation Improves Verbal Fluency and Written Language in a Patient with Primary Progressive Aphasia-Logopenic Variant (LPPA)

Excitatory Deep Transcranial Magnetic Stimulation with H-Coil Over the Right Homologous Broca’s Region Improves Naming in Chronic Post-Stroke Aphasia

Sequential l-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst DTMS For Highly-Suicidal Treatment-Resistant Depression Patients

Sequential L-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst dTMS for Suicidal Highly Treatment Resistant Depression Patients

Deep-TMS Add-On Treatment for Intractable Tourette syndrome: A Feasibility Study

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