All Clinical Research

Mental Health / Psychiatry

Depression

Peer-reviewed studies and reviews on Deep TMS for Depression.

Showing Depression  ·  37–54 of 95

  1. A Comparison of rTMS and dTMS Treatment Outcomes for Major Depressive Disorder in a Real-World Clinical Practice Setting

    Wirecki T, Stephenson C, Seale R, Davis L

    Brain Stimulation  ·  2015

    The comparative efficacy of rTMS and dTMS is a topic of debate among practitioners. Data from real-world clinical settings can be informative.   Objective: To compare rTMS and dTMS devices for the treatment of MDD.  Methods: This study included two groups of patients with MDD. Group 1 included 45 patients (30%…

    Depression
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  2. Examining Relationship Between Prior Lifetime Electroconvulsive Therapy and dTMS Treatment Outcomes in Major Depressive Disorder Patients Using H-Coil Technology in a Naturalistic Clinical Setting

    Duffy W, Choudhry Z, Rajamani M, Nathan R, Siddiqui W, Waris M

    Brain Stimulation  ·  2015

    Electroconvulsive Therapy (ECT) is believed to be an effective treatment for treatment resistant depression (TRD). However, ECT has been associated with major side-effects including cognitive sequel. Alternatively, deep Transcranial Magnetic Stimulation (dTMS) is another effective treatment for alleviating MDD symptoms. Reports comparing efficacy…

    Depression
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  3. Improvement in Quality of life Outcomes in Patients with Major Depressive Disorder Using dTMS Treatment in a Real-world Clinical Setting

    Duffy W, Choudhry Z, Rajamani M, Nathan R, Siddiqui W, Waris M

    Brain Stimulation  ·  2015

    Currently, pharmacotherapy is the first-line treatment for Major Depressive Disorder (MDD). However, review of clinical studies has revealed that 2/3 of MDD patients do not respond sufficiently to pharmacotherapy alone. This in turn, has a considerable impact on MDD patients’ overall wellbeing and Quality of Life (QOL).…

    Depression
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  4. Investigating the Effect of Caffeine on dTMS Treatment Outcomes in Major Depressive Disorder Patients in a Real-world Clinical Setting

    Duffy W, Choudhry Z, Rajamani M, Nathan R, Siddiqui W, Waris M

    Brain Stimulation  ·  2015

    A positive correlation between caffeine consumption and depression was recently reported. Biologically, caffeine inhibits adenosine A1 and A2A receptors. Researchers link A2A receptors with depression pathogenesis. They suggest a tight interaction between A2A receptors and Trk-B receptors which are upstream of Brain-Derived Neurotrophic…

    Depression
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  5. Deep TMS for comorbid Major Depressive Disorder and Anxiety - A Brief Report of Patients in a Real-World Practice

    Hovav S, Kinback K

    Brain Stimulation  ·  2014

    Deep Transcranial Magnetic Stimulation (dTMS) received FDA clearance in 2013 for the treatment of depression. As of yet, there are no post-marketing outcome data in “real world” practices.   Objective: To examine a retrospective cohort of ten patients, ages 20-74, who received dTMS for treatment-resistant major depressive…

    AnxietyDepression
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  6. Efficacy of Deep TMS for the Treatment of Depression in a Real-world Clinical Practice Setting

    Stephenson C, Wirecki T, Levy A, Choudhry Z, Duffy W

    Brain Stimulation  ·  2014

    The efficacy of deep TMS (dTMS) in depression has been shown in clinical trials. However, few dTMS studies have been conducted in naturalistic settings.   Objective: To review response rates to dTMS treatment in a real-world clinical practice setting.  Methods: This study includes eight patients, ages 25 to 57…

    Depression
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  7. Therapeutic Outcomes of dTMS Therapy Using H-Coil Technology in Patients with Major Depressive Disorder; a Naturalistic Clinical Study

    Duffy W, Choudhry Z, Nathan R, Conroy M, Duffy W, Huynh W

    Brain Stimulation  ·  2014

    Deep TMS (dTMS) clinical trials using H-coil technology in Major depressive disorder (MDD) patients has shown significant outcomes following standardized treatment protocols. However, in naturalistic settings physicians adapt treatment protocols to individual clinical considerations achieving better outcomes. These varied therapeutic strategies may inform other physicians…

    Depression
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  8. Effectiveness of a second deep TMS in depression: A brief report

    Rosenberg O, Isserles M, Levkovitz Y, Kotler M, Zangen A, Dannon PN

    Progress in Neuro-Psychopharmacology & Biological Psychiatry  ·  2011

    Deep transcranial magnetic stimulation (dTMS) is an emerging and promising treatment for major depression. In our study, we explored the effectiveness of a second antidepressant course of dTMS in major depression.  Objective: To evaluate whether a second course of dTMS would be effective.  Methods: Eight depressive patients who relapsed…

    Depression
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  9. Safety and efficacy of Deep TMS for adolescent depression based on large real-world data analysis

    Yiftach Roth, Aron Tendler, Gaby S. Pell, TeeJay Tripp, Philip Yam,  Dianne DeKeyser, Mah Mekolle, Jayson Tripp, et al.

    Psychiatry Research  ·  2025

    Adolescent depression is a critical and growing public health concern, with high rates of treatment resistance and limited effective interventions. Deep Transcranial Magnetic Stimulation (Deep TMS) has been previously validated for adults, but data on its use in adolescents remain limited. Objective:To…

    Depression
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  10. Efficacy and Safety of Deep Transcranial Magnetic Stimulation Versus High-Frequency Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder: A Systematic Review

    Nan Zhang, Yu Mo, Xian-Jun Lan, Qi-Man Liu, Wen-Xiu Li, Xing-Bing Huang, Hua-Wang Wu, Shi-Chao Xu, et al.

    Current Behavioral Neuroscience Reports

    This systematic review aimed to evaluate and compare the safety and effectiveness of deep transcranial magnetic stimulation (dTMS) with high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for individuals diagnosed with major depressive disorder (MDD).  The study was motivated by the inconsistent findings of prior studies comparing  dTMS and HF-rTMS  for depression treatment. The…

    Depression
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  11. Deep TMS for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness

    Michelle Thai, Aparna U. Nair, Bonnie Klimes-Dougan, C. Sophia Albott, Thanharat Silamongkol, Michelle Corkrum, Dawson Hill, Justin W. Roemer, et al.

    Thai, et al. Journal of Affective Disorders  ·  2024

    Transcranial magnetic stimulation (TMS) is an intervention for treatment-resistant depression (TRD) that modulates neural activity. Deep TMS (dTMS) can target not only cortical but also deeper limbic structures implicated in depression. Although TMS has demonstrated safety in adolescents, dTMS has yet to…

    Depression
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  12. Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial

    Tyler S. Kaster, Zafiris J. Daskalakis, Yoshihiro Noda, Yuliya Knyahnytska, Jonathan Downar, Tarek K. Rajji, Yechiel Levkovitz, Abraham Zangen, et al.

    Neuropsychopharmacology  ·  2018

    Late-life depression (LLD) is a growing worldwide problem due to demographic changes, with limited treatment options due to high rates of pharmacotherapy adverse effects, accessibility of psychotherapy, and tolerability of electroconvulsive therapy. Novel neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS),…

    Depression
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  13. Never Too Late: Safety and Efficacy of Deep TMS for Late-Life Depression

    Yiftach Roth, Faisal Munasifi, Steven A. Harvey, Geoffrey Grammer, Colleen A. Hanlon and Aron Tendler

    Journal of Clinical Medicine  ·  2024

    Repetitive transcranial magnetic stimulation (rTMS) is an effective and well-established treatment for major depressive disorder (MDD). Deep TMS utilizes specially designed H-Coils to stimulate the deep and broad cerebral regions associated with the reward system. The improved depth penetration of Deep TMS…

    Depression
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  14. Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study

    Nathaniel A. Shanok, Sabrina Muzac, Leah Brown, Melissa Barrera, Raul Rodriguez

    Psychopharmacology  ·  2024

    Major Depressive Disorder (MDD) is a pervasive psychiatric condition effecting approximately 21 million adults in the U.S. (8.4%). An estimated 30–60% of patients are resistant to traditional treatment approaches (medications and talk-therapy), alluding to the need for additional options. Two promising treatment…

    Depression
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  15. Depressive symptoms during deep transcranial magnetic stimulation or sham treatment for obsessive-compulsive disorder

    Orri Smárason,  Peter J. Boedeker,  Andrew G. Guzick,  Aron Tendler,  Sameer A. Sheth,  Wayne K. Goodman,  Eric A. Storch

    Journal of Affective Disorders  ·  2024

    Evidence suggests that depressive symptoms tend to improve concurrently with obsessive-compulsive disorder (OCD) symptoms during cognitive behavioral therapy (CBT), despite depression not being the primary target of intervention. Studies examining the temporal or mediational relationships of OCD and depressive symptoms have indicated…

    DepressionOCD
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  16. Durability of Deep Transcranial Magnetic Stimulation for Veterans with Treatment-Resistant Depression with Comorbid Suicide Risk and PTSD Symptoms

    Robert Hickson, Max W. Simonsen, Kenneth J. Miller, Michelle R. Madore

    Psychiatry Research  ·  2024

    The background highlights the challenges faced by veterans with TRD, suicide risk, and PTSD symptoms, emphasizing the need for effective and durable treatment options. Objective: The primary objective is to assess the durability of deep transcranial magnetic stimulation in improving symptoms of…

    DepressionPTSD
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  17. Are There Stages of Depression?

    It is normal for people to feel sad occasionally or have less enthusiasm for tasks that they once loved to do. However, when these feelings persist for an extended period, they may be a symptom of depression. Depression isn’t a defect of…

    Depression
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  18. Deep transcranial magnetic stimulation alters resting-state neurophysiological traits in major depressive disorder

    Nathaniel A. Shanok, Santiago Rodriguez, Sabrina Muzac, Carla Huertas Del Pino, Leah Brown, Raul Rodriguez

    Journal of Affective Disorders  ·  2023

    Major depressive disorder (MDD) stands as one of the most prevalent and incapacitating health conditions globally, and regrettably, numerous patients do not exhibit positive responses to traditional antidepressant medication or talk therapy approaches. Deep transcranial magnetic stimulation (Deep TMS) has emerged as…

    Depression
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