Mental Health / Psychiatry
Peer-reviewed studies and reviews on Deep TMS for Depression.
Showing Depression · 19–36 of 95
TMS-EEG is a rapidly growing area that can be used to assess cortical activity in response to TMS pulses with high temporal resolution. Objective: To evaluate EEG features following single dTMS pulses as a potential biomarker for treatment outcome in MDD patients. Methods: 27 healthy controls and…
Chronic treatment resistant depression takes a substantial toll on patients' quality of life and alternative treatment options are limited. Objective: This prospective multicenter study evaluated the safety, tolerability and efficacy of four weeks of thrice-a-week deep transcranial magnetic stimulation (dTMS) in combination with selective serotonin reuptake…
One of the strategies used for optimizing rTMS treatment for depression is combining rTMS with other evidence-based modalities. The use of light for depression dates back to the beginnings of civilization. Since the first description of the syndrome of Seasonal affective disorder (SAD) and light therapy in the seminal paper by Rosenthal, Bright Light Therapy…
Recently, several dTMS trials on TRD have been published, including two randomized-control trials (RCTs) (Filipcic et al., 2019; Kaster et al., 2018) and two open-label trials (Rapinesi et al., 2018; Tendler et al., 2018). It is important to update the summarized effect of dTMS in patients with TRD. Objective: This study aimed to investigate whether dTMS improves…
Major depression is a highly prevalent disorder that causes economic burden in office workers. Objective: To evaluate the efficacy and safety of deep transcranial magnetic stimulation (dTMS) in office workers with treatment-resistant depression. Methods: This study was a randomized, double-blind, sham-controlled trial and recruited office workers…
Despite the availability of Deep TMS for MDD since 2013 when it was cleared by the FDA, its real-world clinical practice efficacy is unknown. Objective: To demonstrate the real-world clinical practice efficacy of Deep TMS H1 Coil for MDD. Methods: All Deep TMS sites were offered compensation for treatment and outcome data. Outcome…
Nearly half of the patients with depression experience suboptimal benefits from antidepressants. Neuromodulation therapies, a kind of technology that can regulate neuronal firing activity by electrical or magnetic stimulation, were introduced to improve this situation. However, the results from clinical trials have been…
Repetitive transcranial magnetic stimulation (TMS) is an evidence-based treatment for pharmacoresistant major depressive disorder (MDD), however, the evidence in veterans has been mixed. Objective: The VA implemented a nationwide TMS program that included evaluating clinical outcomes within a naturalistic design. TMS was hypothesized to be…
High-frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC) using a figure-of-8 or an H1-coil (deep TMS) is an efficient method of treatment for depression, with A level evidence of efficacy, approved for treating Major Depressive Disorder (MDD) in adults who have not responded to prior antidepressant medications Objective: This…
F-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex…
The efficacy of transcranial magnetic stimulation (TMS) for depression may depend on targeting specific brain circuits. However, this has not been tested for TMS with the H1 coil, a widely used device believed to target more broadly and deeply than TMS with…
The current FDA-cleared TMS protocols for TRD target primarily the left DLPFC. These protocols fail to benefit a large population of TRD patients, probably due to the heterogeneity of the disorder that affects multiple cortical and subcortical networks. As such, novel approaches and targets are required in the treatment of MDD…
Various non-invasive repetitive transcranial magnetic stimulation (rTMS) methods have been approved for treatment-resistant unipolar depression. Objective: To compare the efficacy of two rTMS coils (H1-coil vs. F8-coil) using a systematic review and meta-analysis. Methods: Following a systematic search of PsycInfo and Medline (until July, 2016), 17 studies using…
Deep transcranial magnetic stimulation (dTMS) with H-coil is a noninvasive stimulation of presumably deep brain regions. Objective: To systematically review the literature on the neurobiological mechanisms of dTMS. Methods: Following a systematic literature search of PsycInfo and Medline (until August 2016) and hand search, k=8 open-label studies and…
A patient with lifelong treatment-resistant mood disorder and social anxiety was treated successfully with intranasal ketamine for several months until side effects became intolerable. During a recurrence of depression, treatment with dTMS led to full and durable recovery. The authors used QEEG to directly observe changes in brain…
There are two primary FDA-approved TMS devices: Neurostar and Brainsway deep TMS (dTMS). They are comparable in mode of operation and system for delivery of electromagnetic fields to the prefrontal cortex. They differ in depth and breadth of penetration into the cortex. The Brainsway dTMS penetrates up to 8 cm deep compared…
A previously published study suggests lower rates of response and remission in six patients who previously failed a course of ECT. Objective: To further evaluate efficacy of deep transcranial magnetic stimulation (dTMS) for patients with highly treatment resistant severe depression – those…
Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses electromagnetic coils to stimulate areas of the brain non-invasively. Deep transcranial magnetic stimulation (dTMS) with the Brainsway H1coil system specifically is a type of rTMS indicated for treating patients with major depressive disorder…
