Showing Clinical Research · 19–36 of 292
Late-life depression (LLD) is a prevalent and often underdiagnosed condition in older adults, associated with significant cognitive, functional, and medical burdens. Conventional treatments frequently present limitations in this population, underscoring the need for safer, more effective alternatives. Objective: This review evaluates the…
Adaptive decision making requires the adjustment of behavior following an error in order to improve future performance, but OCD patients are characterized by abnormal error monitoring. For example, in cognitive tasks like Flanker or Stroop, reaction time (RT) following commission of an…
Transcranial magnetic stimulation (TMS) uses magnetic pulses to induce electrical current in the underlying neuronal tissue. A variety of TMS coils exist on the market, differing primarily in configuration, orientation, and flexibility of the wire windings of the coil. Deep TMSTM utilizes…
Deep transcranial magnetic stimulation (dTMS) is a modern non-invasive brain stimulation method demonstrated as effective in the treatment of major depression and obsessive-compulsive disorder (OCD). Objective: This review aims to survey present knowledge concerning the cognitive function changes identified in dTMS research. …
A group of European experts reappraised the guidelines on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 Methods: These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed…
Tobacco smoking remains a leading preventable cause of morbidity and mortality worldwide. Deep transcranial magnetic stimulation (DTMS) using the H4 coil targets addiction-related circuits within the bilateral insula and prefrontal cortex and has demonstrated safety and efficacy in reducing smoking craving. However,…
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for several mental health conditions including substance use disorders. Symptom provocation before rTMS is hypothesized to activate disease-related neurocircuitry and enhance treatment effects. For addiction, craving induction is frequently used before treatment, but…
In 2020, Deep Transcranial Magnetic Stimulation (Deep TMS) gained FDA clearance for short-term smoking cessation, demonstrating efficacy comparable to pharmacotherapies with minimal side effects. Objective: This Phase IV registry study aimed to assess the real-world feasibility and efficacy of Deep TMS for…
Pathological gambling is classified in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, as an impulse- control disorder. Several studies showed positive preliminary results using TMS to treat addictions. Because TMS is a potential treatment for addictions, and because frontal cortex activity may be abnormal in pathological gamblers compared…
Cue-Restricted Smoking (CRS) is a behavioral technique for smoking cessation that has shown efficacy as an adjunct to pharmacotherapy. In CRS, individuals limit smoking to a standing position while facing a wall in an isolated environment devoid of sensory stimulation. Objective: This…
Chronic cocaine consumption is associated with a decrease in mesolimbic dopamine transmission that maintains drug intake. TMS is gaining reliability, a useful therapeutic tool in drug addiction, since it can modulate cortico-limbic activity resulting in reduction of drug craving. Objective: This study…
Behavioral and neurobiological abnormalities in addiction and obesity have led to the theory of food addiction in obesity (FAOB) and brain-behavior association studies. Transcranial magnetic stimulation (TMS) studies and treats various brain disorders. Cortico-cortical paired associative stimulation (ccPAS) TMS protocol, in which…
Current approved therapies for smoking cessation have modest long-term effects for abstinence. The insular cortex has been identified by preclinical and clinical studies as a critical target for addiction treatment. Insula functions can be modulated non-invasively using brain stimulation. Objective: To describe a protocol for deep repetitive…
Obesity is highly prevalent in patients with schizophrenia and, in association with metabolic syndrome, contributes to premature deaths of patients due to cardiovascular disease complications. Moreover, pharmacologic, and behavioral interventions have not stemmed the tide of obesity in schizophrenia. Therefore, novel effective interventions are urgently needed.…
Cocaine dependence is a substantial public health problem. Objective: The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods: Seven men with CUD and no concurrent…
Transcranial magnetic stimulation (TMS) is increasingly used off-label for posttraumatic stress disorder (PTSD), often applying protocols developed for depression. While prior studies suggest high-frequency TMS can improve PTSD symptoms, few have been adequately powered to compare protocols. We examined whether three common TMS protocols yield…
Data suggests that the available therapeutic tools are still insufficient to deal with suicidality. Non-Invasive Brain Stimulation techniques (NIBS) have entered the recognized guidelines for therapies in psychiatry due to the advantages related to safety and tolerability. Objective: The purpose of this…
Suicidality is a leading cause of death in major depressive disorder (MDD), yet actively suicidal patients are rarely included in neuromodulation trials. Evidence for deep transcranial magnetic stimulation (dTMS) in this group is limited. Objective: To assess the safety and efficacy of…
