Showing Clinical Research · 19–36 of 303
Growing evidence highlights the crucial role of gut microbiota in affecting different aspects of obesity. Potential mechanisms for microbial control over eating behavior include microbiota influence on reward and satiety pathways, neurotransmitters release, and hypothalamic-pituitary-adrenal (HPA) axis modulation. dTMS is a methodology proved to be effective in modulating…
Obesity has reached epidemic proportions, becoming a global health concern. Promising results have been obtained by the application of Deep TMS in reducing nicotine dependence, alcohol craving, and cocaine abuse. Consistent with the dysregulation of the prefrontal cortex inhibitory control and brain…
Anorexia nervosa (AN) is a complex disorder of unknown etiology, characterized by obsessions and compulsions around body shape, weight, and calorie intake. In the course of AN, 10%-30% will recover, while the rest will develop a treatment-resistant course with a high mortality…
Obesity is known to be associated with an altered thermoregulation as well as a dysregulation of sympathetic nervous system (SNS). Considering the ability of deep transcranial magnetic stimulation (dTMS) to modulate the SNS, we hypothesized a potential role of dTMS in affecting…
In obesity, metabolic and voluntary factors regulate appetite, and a dysregulation of the reward pathway was demonstrated in all addiction disorders. Deep transcranial magnetic stimulation (dTMS) is already used to modulate cerebral dopamine activation in neuro-psychiatric diseases. Objective: To assess the acute…
Seizures are rare during repetitive transcranial magnetic stimulation (rTMS) treatment, but estimating risk is difficult because of study heterogeneity and sampling limitations. Moreover, there are few studies comparing rates between device manufacturers. Objective: The objective of this study was to calculate rTMS…
Major Depressive Disorder (MDD) and Alzheimer's disease (AD) represent two of the most prevalent diseases worldwide. Notably, it is estimated that 30%-50% of individuals with AD have co-occurring MDD and there are overlapping symptoms across numerous domains. Methods: In this pilot study,…
The optimal dose (number of pulses per session) of repetitive transcranial magnetic stimulation (rTMS), using the H-coil, in major depressive disorder (MDD) has not previously been reported. Objective: To explore the relationship between rTMS dose and antidepressant effect, and collect data for…
Brainsway dTMS is FDA approved for TRD. Multiple studies prove the efficacy of Ketamine in TRD. There are case reports discussing the combination between Ketamine and rTMS in TRD Objective: To assess the clinical impact of Brainsway dTMS and Brainsway dTMS combined…
Major depressive disorder (MDD) is a leading cause of global disability and is notably prevalent in older adults. Deep transcranial magnetic stimulation (dTMS), specifically the H1-coil targeting the lateral prefrontal cortex, is approved for adults with treatment-resistant MDD and has shown promise…
Recruitment challenges are inherent in clinical research, and are particularly pronounced in older adults with depression, who often face unique barriers such as medical comorbidities and infrequent help-seeking behaviour. Neurostimulation techniques, like deep transcranial magnetic stimulation (dTMS), are often unfamiliar to patients…
Late-life depression (LLD) is a prevalent and often underdiagnosed condition in older adults, associated with significant cognitive, functional, and medical burdens. Conventional treatments frequently present limitations in this population, underscoring the need for safer, more effective alternatives. Objective: This review evaluates the…
Adaptive decision making requires the adjustment of behavior following an error in order to improve future performance, but OCD patients are characterized by abnormal error monitoring. For example, in cognitive tasks like Flanker or Stroop, reaction time (RT) following commission of an…
Transcranial magnetic stimulation (TMS) uses magnetic pulses to induce electrical current in the underlying neuronal tissue. A variety of TMS coils exist on the market, differing primarily in configuration, orientation, and flexibility of the wire windings of the coil. Deep TMSTM utilizes…
Deep transcranial magnetic stimulation (dTMS) is a modern non-invasive brain stimulation method demonstrated as effective in the treatment of major depression and obsessive-compulsive disorder (OCD). Objective: This review aims to survey present knowledge concerning the cognitive function changes identified in dTMS research. …
A group of European experts reappraised the guidelines on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) previously published in 2014 Methods: These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed…
Tobacco smoking remains a leading preventable cause of morbidity and mortality worldwide. Deep transcranial magnetic stimulation (DTMS) using the H4 coil targets addiction-related circuits within the bilateral insula and prefrontal cortex and has demonstrated safety and efficacy in reducing smoking craving. However,…
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for several mental health conditions including substance use disorders. Symptom provocation before rTMS is hypothesized to activate disease-related neurocircuitry and enhance treatment effects. For addiction, craving induction is frequently used before treatment, but…
