Mental Health Conditions
Peer-reviewed studies and reviews on Deep TMS for Obsessive Compulsive Disorder (OCD).
Showing Obsessive Compulsive Disorder (OCD) · 1–18 of 39
In obsessive-compulsive disorder (OCD), glutamatergic neurotransmission dysfunction played key roles in pathophysiology. Objective: The current research assessed changes of neurometabolites in the bilateral striatum of OCD patients receiving low-frequency repetitive transcranial magnetic stimulation (rTMS) using 1H proton magnetic resonance spectroscopy (1H-MRS). Methods: 52 OCD…
Evidence is accumulating in support of the use of TMS for the treatment of OCD. The anterior cingulate cortex (ACC) is the brain target of choice for OCD because it is central in the processing of negative emotions including fear and threat,…
Recently the H7 dTMS coil was FDA approved for adjunctive treatment of adults with OCD based a multicenter sham-controlled study 100 adults. Will these findings hold up in a naturalistic setting? Objective: Retrospective chart review of adolescent and adult patients who received…
dTMS for obsessive-compulsive disorder (OCD) with the H7 coil has been shown to be efficacious in pilot and multicenter double-blinded clinical trials. How do patients fair in a naturalistic setting? Objective: Retrospective patient chart review who received open label dTMS for OCD…
Deep transcranial magnetic stimulation (dTMS) is designed to stimulate broader and deeper brain regions than conventional TMS. While dTMS had emerged as a promising option for obsessive-compulsive disorder (OCD), high-quality evidence on its efficacy and safety in treatment-resistant OCD remained limited. Objective: This meta-analysis evaluated the efficacy and…
Brain morphological biomarkers could contribute to understanding the treatment response in patients with obsessive-compulsive disorder (OCD). Multimodal neuroimaging addresses this issue by providing more comprehensive information regarding neural processes and structures. Objective: The study aimed to investigate whether patients responsive to deep Transcranial Magnetic Stimulation (TMS)…
Obsessive-compulsive disorder (OCD) affects 1.1-1.8% of the population, and adult females are more likely to suffer from it. Deep transcranial magnetic stimulation (dTMS) stimulates dorsomedial prefrontal cortex and anterior cingulate cortex - two frontal brain networks implicated in OCD. Objective: The study aimed to identify a…
MDD is the most common comorbidity with OCD; more than 50% of OCD patients meet lifetime criteria for MDD or dysthymia. Depression can significantly worsen OCD treatment outcomes and elevate the risk for suicide. While the multi-center-tested and FDA indicated Deep TMS treatment for OCD uses the H7 Coil to target dorsomedial prefrontal cortex…
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique receiving increasing attention in the treatment of different psychiatric disorders. Evidence for rTMS use in obsessive-compulsive disorder (OCD) is accumulating and informing further developments in the neurostimulation field, the latest being deep…
A substantial proportion of patients with OCD remain symptomatic despite pharmacotherapy and psychotherapy. Brain stimulation approaches have therefore been investigated as adjunctive strategies for refractory illness. Objective: This systematic review examined the evidence for brain stimulation techniques in OCD, including transcranial magnetic…
Deep TMS has emerged as a treatment option for adults with OCD who continue to exhibit impairing symptoms following an adequate response to first line interventions. Currently, little is known about the predictors or moderators of Deep TMS outcome for OCD. Objective:…
The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. Objective:…
Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive-compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical-striatal-thalamic-cortical loop circuits in OCD, several randomized controlled trials (RCTs) have addressed the efficacy of different non-invasive brain stimulation…
Current FDA-cleared TMS protocols for OCD include symptom provocation before stimulation, based on the idea that brain state may influence TMS effects. However, the size of any added clinical benefit from provocation had not been quantified across the literature. Objective: This systematic…
Obsessive-Compulsive Disorder (OCD) significantly impairs patients’ quality of life and frequently co-occurs with Major Depressive Disorder (MDD), complicating the interpretation of treatment outcomes. Transcranial Magnetic Stimulation (TMS) is FDA-approved for treatment-resistant OCD; however, there is limited naturalistic data on its effectiveness or predictors of…
Deep repetitive transcranial magnetic stimulation (DTMS), using the H7 coil, is an approved treatment for obsessive-compulsive disorder (OCD) by the United States Food and Drug Administration (US-FDA). The clinical efficacy and safety of accelerated regimens of DTMS have been previously studied extensively.…
Obsessive-compulsive disorder is one of the most common neuropsychiatric disorders with a higher lifetime prevalence than schizophrenia, often showing inadequate response to pharmacological and psychotherapeutic treatments. Objective: This study aimed to examine the efficacy of adjunctive deep transcranial magnetic stimulation (dTMS) in…
