Clinical Research
Peer-reviewed studies and reviews on Deep TMS for Mental Health Conditions.
Showing Mental Health Conditions · 19–36 of 187
Aerobic exercise (AEx) is effective in reducing depressive symptoms whether employed singularly or with other anti-depressant treatments. The safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression is also well documented. Given the benefits of both AEx and rTMS individually, it seems plausible that…
MDD is the most common comorbidity with OCD; more than 50% of OCD patients meet lifetime criteria for MDD or dysthymia. Depression can significantly worsen OCD treatment outcomes and elevate the risk for suicide. While the multi-center-tested and FDA indicated Deep TMS treatment for OCD uses the H7 Coil to target dorsomedial prefrontal cortex…
The DSM-5 classifies MDD as a depressed mood or a loss of interest or pleasure in daily activities for more than two consecutive weeks. Due to the nature of symptoms associated with major depression, many studies have looked at the correlation between…
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique with few side effects that has been reported to be effective in the treatment of major depressive disorder (MDD). At present, no randomized controlled trials (RCT) have compared the efficacy and safety of rTMS delivered by the…
Depressed patients who fail pharmacotherapy and non-invasive brain stimulation, such as TMS and ECT, have limited treatment options. Because depression affects multiple cortical and subcortical networks, multifocal deep TMS (dTMS) may have efficacy in such patients. Methods: A 25 year-old-woman diagnosed with bipolar…
Currently available therapeutic modalities for alcohol use disorder (AUD) produce limited effect sizes, particularly when long-term relapse prevention is considered. Following recognition of AUD as a brain disease and advances in understanding of related pathological neural circuitries, methods that were developed to modulate brain…
TMS-EEG is a rapidly growing area that can be used to assess cortical activity in response to TMS pulses with high temporal resolution. Objective: To evaluate EEG features following single dTMS pulses as a potential biomarker for treatment outcome in MDD patients. Methods: 27 healthy controls and…
Chronic treatment resistant depression takes a substantial toll on patients' quality of life and alternative treatment options are limited. Objective: This prospective multicenter study evaluated the safety, tolerability and efficacy of four weeks of thrice-a-week deep transcranial magnetic stimulation (dTMS) in combination with selective serotonin reuptake…
One of the strategies used for optimizing rTMS treatment for depression is combining rTMS with other evidence-based modalities. The use of light for depression dates back to the beginnings of civilization. Since the first description of the syndrome of Seasonal affective disorder (SAD) and light therapy in the seminal paper by Rosenthal, Bright Light Therapy…
Recently, several dTMS trials on TRD have been published, including two randomized-control trials (RCTs) (Filipcic et al., 2019; Kaster et al., 2018) and two open-label trials (Rapinesi et al., 2018; Tendler et al., 2018). It is important to update the summarized effect of dTMS in patients with TRD. Objective: This study aimed to investigate whether dTMS improves…
Major depression is a highly prevalent disorder that causes economic burden in office workers. Objective: To evaluate the efficacy and safety of deep transcranial magnetic stimulation (dTMS) in office workers with treatment-resistant depression. Methods: This study was a randomized, double-blind, sham-controlled trial and recruited office workers…
Despite the availability of Deep TMS for MDD since 2013 when it was cleared by the FDA, its real-world clinical practice efficacy is unknown. Objective: To demonstrate the real-world clinical practice efficacy of Deep TMS H1 Coil for MDD. Methods: All Deep TMS sites were offered compensation for treatment and outcome data. Outcome…
Nearly half of the patients with depression experience suboptimal benefits from antidepressants. Neuromodulation therapies, a kind of technology that can regulate neuronal firing activity by electrical or magnetic stimulation, were introduced to improve this situation. However, the results from clinical trials have been…
Repetitive transcranial magnetic stimulation (TMS) is an evidence-based treatment for pharmacoresistant major depressive disorder (MDD), however, the evidence in veterans has been mixed. Objective: The VA implemented a nationwide TMS program that included evaluating clinical outcomes within a naturalistic design. TMS was hypothesized to be…
High-frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC) using a figure-of-8 or an H1-coil (deep TMS) is an efficient method of treatment for depression, with A level evidence of efficacy, approved for treating Major Depressive Disorder (MDD) in adults who have not responded to prior antidepressant medications Objective: This…
F-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex…
The efficacy of transcranial magnetic stimulation (TMS) for depression may depend on targeting specific brain circuits. However, this has not been tested for TMS with the H1 coil, a widely used device believed to target more broadly and deeply than TMS with…
The current FDA-cleared TMS protocols for TRD target primarily the left DLPFC. These protocols fail to benefit a large population of TRD patients, probably due to the heterogeneity of the disorder that affects multiple cortical and subcortical networks. As such, novel approaches and targets are required in the treatment of MDD…
