Clinical Research
Peer-reviewed studies and reviews on Deep TMS for Mental Health / Psychiatry.
Showing Mental Health / Psychiatry · 19–36 of 208
Cue-Restricted Smoking (CRS) is a behavioral technique for smoking cessation that has shown efficacy as an adjunct to pharmacotherapy. In CRS, individuals limit smoking to a standing position while facing a wall in an isolated environment devoid of sensory stimulation. Objective: This…
Chronic cocaine consumption is associated with a decrease in mesolimbic dopamine transmission that maintains drug intake. TMS is gaining reliability, a useful therapeutic tool in drug addiction, since it can modulate cortico-limbic activity resulting in reduction of drug craving. Objective: This study…
Behavioral and neurobiological abnormalities in addiction and obesity have led to the theory of food addiction in obesity (FAOB) and brain-behavior association studies. Transcranial magnetic stimulation (TMS) studies and treats various brain disorders. Cortico-cortical paired associative stimulation (ccPAS) TMS protocol, in which…
Current approved therapies for smoking cessation have modest long-term effects for abstinence. The insular cortex has been identified by preclinical and clinical studies as a critical target for addiction treatment. Insula functions can be modulated non-invasively using brain stimulation. Objective: To describe a protocol for deep repetitive…
Obesity is highly prevalent in patients with schizophrenia and, in association with metabolic syndrome, contributes to premature deaths of patients due to cardiovascular disease complications. Moreover, pharmacologic, and behavioral interventions have not stemmed the tide of obesity in schizophrenia. Therefore, novel effective interventions are urgently needed.…
Cocaine dependence is a substantial public health problem. Objective: The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods: Seven men with CUD and no concurrent…
Transcranial magnetic stimulation (TMS) is increasingly used off-label for posttraumatic stress disorder (PTSD), often applying protocols developed for depression. While prior studies suggest high-frequency TMS can improve PTSD symptoms, few have been adequately powered to compare protocols. We examined whether three common TMS protocols yield…
Data suggests that the available therapeutic tools are still insufficient to deal with suicidality. Non-Invasive Brain Stimulation techniques (NIBS) have entered the recognized guidelines for therapies in psychiatry due to the advantages related to safety and tolerability. Objective: The purpose of this…
Suicidality is a leading cause of death in major depressive disorder (MDD), yet actively suicidal patients are rarely included in neuromodulation trials. Evidence for deep transcranial magnetic stimulation (dTMS) in this group is limited. Objective: To assess the safety and efficacy of…
Promising clinical benefits were observed with d-cycloserine (DCS) augmentation of intermittent theta-burst stimulation (iTBS), presumably by enhancing long-term potentiation (LTP) through NMDA receptor agonism (Cole et al., 2022). However, the applicability of this trial and accessibility of this approach are unknown. Ojective: N/A Methods: N/A Results: We…
There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments…
In obsessive-compulsive disorder (OCD), glutamatergic neurotransmission dysfunction played key roles in pathophysiology. Objective: The current research assessed changes of neurometabolites in the bilateral striatum of OCD patients receiving low-frequency repetitive transcranial magnetic stimulation (rTMS) using 1H proton magnetic resonance spectroscopy (1H-MRS). Methods: 52 OCD…
PTSD is both prevalent and debilitating. While Deep TMS has shown preliminary efficacy, exposure therapy remains the most efficacious, though limited, treatment in PTSD. The medial prefrontal cortex (mPFC) is implicated in extinction learning, suggesting that concurrent mPFC stimulation may enhance exposure therapy. Objective: This randomized controlled multicenter trial set out…
One third of the depressed patients are not improved by antidepressant drugs and psychological treatments, and there is a need for additional treatments. Repetitive transcranial magnetic stimulation (rTMS) is being developed towards an alternative in treatment-resistant depression. Deep transcranial stimulation (dTMS) with the Hesel-coil…
Evidence is accumulating in support of the use of TMS for the treatment of OCD. The anterior cingulate cortex (ACC) is the brain target of choice for OCD because it is central in the processing of negative emotions including fear and threat,…
Recently the H7 dTMS coil was FDA approved for adjunctive treatment of adults with OCD based a multicenter sham-controlled study 100 adults. Will these findings hold up in a naturalistic setting? Objective: Retrospective chart review of adolescent and adult patients who received…
dTMS for obsessive-compulsive disorder (OCD) with the H7 coil has been shown to be efficacious in pilot and multicenter double-blinded clinical trials. How do patients fair in a naturalistic setting? Objective: Retrospective patient chart review who received open label dTMS for OCD…
