Clinical Research
Peer-reviewed studies and reviews on Deep TMS for Mental Health / Psychiatry.
Showing Mental Health / Psychiatry · 55–72 of 208
F-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex…
The efficacy of transcranial magnetic stimulation (TMS) for depression may depend on targeting specific brain circuits. However, this has not been tested for TMS with the H1 coil, a widely used device believed to target more broadly and deeply than TMS with…
The current FDA-cleared TMS protocols for TRD target primarily the left DLPFC. These protocols fail to benefit a large population of TRD patients, probably due to the heterogeneity of the disorder that affects multiple cortical and subcortical networks. As such, novel approaches and targets are required in the treatment of MDD…
Various non-invasive repetitive transcranial magnetic stimulation (rTMS) methods have been approved for treatment-resistant unipolar depression. Objective: To compare the efficacy of two rTMS coils (H1-coil vs. F8-coil) using a systematic review and meta-analysis. Methods: Following a systematic search of PsycInfo and Medline (until July, 2016), 17 studies using…
Deep transcranial magnetic stimulation (dTMS) with H-coil is a noninvasive stimulation of presumably deep brain regions. Objective: To systematically review the literature on the neurobiological mechanisms of dTMS. Methods: Following a systematic literature search of PsycInfo and Medline (until August 2016) and hand search, k=8 open-label studies and…
A patient with lifelong treatment-resistant mood disorder and social anxiety was treated successfully with intranasal ketamine for several months until side effects became intolerable. During a recurrence of depression, treatment with dTMS led to full and durable recovery. The authors used QEEG to directly observe changes in brain…
There are two primary FDA-approved TMS devices: Neurostar and Brainsway deep TMS (dTMS). They are comparable in mode of operation and system for delivery of electromagnetic fields to the prefrontal cortex. They differ in depth and breadth of penetration into the cortex. The Brainsway dTMS penetrates up to 8 cm deep compared…
A previously published study suggests lower rates of response and remission in six patients who previously failed a course of ECT. Objective: To further evaluate efficacy of deep transcranial magnetic stimulation (dTMS) for patients with highly treatment resistant severe depression – those…
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique receiving increasing attention in the treatment of different psychiatric disorders. Evidence for rTMS use in obsessive-compulsive disorder (OCD) is accumulating and informing further developments in the neurostimulation field, the latest being deep…
A substantial proportion of patients with OCD remain symptomatic despite pharmacotherapy and psychotherapy. Brain stimulation approaches have therefore been investigated as adjunctive strategies for refractory illness. Objective: This systematic review examined the evidence for brain stimulation techniques in OCD, including transcranial magnetic…
Deep TMS has emerged as a treatment option for adults with OCD who continue to exhibit impairing symptoms following an adequate response to first line interventions. Currently, little is known about the predictors or moderators of Deep TMS outcome for OCD. Objective:…
Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses electromagnetic coils to stimulate areas of the brain non-invasively. Deep transcranial magnetic stimulation (dTMS) with the Brainsway H1coil system specifically is a type of rTMS indicated for treating patients with major depressive disorder…
The comparative efficacy of rTMS and dTMS is a topic of debate among practitioners. Data from real-world clinical settings can be informative. Objective: To compare rTMS and dTMS devices for the treatment of MDD. Methods: This study included two groups of patients with MDD. Group 1 included 45 patients (30%…
Electroconvulsive Therapy (ECT) is believed to be an effective treatment for treatment resistant depression (TRD). However, ECT has been associated with major side-effects including cognitive sequel. Alternatively, deep Transcranial Magnetic Stimulation (dTMS) is another effective treatment for alleviating MDD symptoms. Reports comparing efficacy…
Currently, pharmacotherapy is the first-line treatment for Major Depressive Disorder (MDD). However, review of clinical studies has revealed that 2/3 of MDD patients do not respond sufficiently to pharmacotherapy alone. This in turn, has a considerable impact on MDD patients’ overall wellbeing and Quality of Life (QOL).…
A positive correlation between caffeine consumption and depression was recently reported. Biologically, caffeine inhibits adenosine A1 and A2A receptors. Researchers link A2A receptors with depression pathogenesis. They suggest a tight interaction between A2A receptors and Trk-B receptors which are upstream of Brain-Derived Neurotrophic…
The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. Objective:…
Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive-compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical-striatal-thalamic-cortical loop circuits in OCD, several randomized controlled trials (RCTs) have addressed the efficacy of different non-invasive brain stimulation…
