Clinical Research
Peer-reviewed studies and reviews on Deep TMS for Mental Health Conditions.
Showing Mental Health Conditions · 55–72 of 187
The efficacy of deep TMS (dTMS) in depression has been shown in clinical trials. However, few dTMS studies have been conducted in naturalistic settings. Objective: To review response rates to dTMS treatment in a real-world clinical practice setting. Methods: This study includes eight patients, ages 25 to 57…
Deep TMS (dTMS) clinical trials using H-coil technology in Major depressive disorder (MDD) patients has shown significant outcomes following standardized treatment protocols. However, in naturalistic settings physicians adapt treatment protocols to individual clinical considerations achieving better outcomes. These varied therapeutic strategies may inform other physicians…
Deep transcranial magnetic stimulation (dTMS) is an emerging and promising treatment for major depression. In our study, we explored the effectiveness of a second antidepressant course of dTMS in major depression. Objective: To evaluate whether a second course of dTMS would be effective. Methods: Eight depressive patients who relapsed…
Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil…
Deep repetitive transcranial magnetic stimulation (DTMS), using the H7 coil, is an approved treatment for obsessive-compulsive disorder (OCD) by the United States Food and Drug Administration (US-FDA). The clinical efficacy and safety of accelerated regimens of DTMS have been previously studied extensively.…
Obsessive-compulsive disorder is one of the most common neuropsychiatric disorders with a higher lifetime prevalence than schizophrenia, often showing inadequate response to pharmacological and psychotherapeutic treatments. Objective: This study aimed to examine the efficacy of adjunctive deep transcranial magnetic stimulation (dTMS) in…
Obsessive-compulsive disorder (OCD) is a chronic debilitating mental illness with waxing and waning courses. The H7 coil used for deep repetitive transcranial magnetic stimulation (dTMS) is designed to produce deeper and broader neuronal stimulation in the dorsomedial prefrontal cortex and anterior cingulate…
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. Objective: To investigate which brain regions…
Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a…
Insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. Objective: This study investigated the potential efficacy of rTMS targeting the insula in alcohol addiction. Methods: Treatment-seeking alcohol-dependent patients (Diagnostic and Statistical Manual of Mental…
Excessive alcohol consumption is a global health concern, with an estimated 400 million people living with alcohol use disorder (AUD). Current treatments for AUD have limited efficacy and fail to address its diverse neurobiological underpinnings. There are at least two cortico-striatal circuits…
Negative symptoms of schizophrenia are disabling and respond inadequately to antipsychotic treatment. Hypofunctioning of cortical areas such as anterior cingulate cortex and medial prefrontal cortex has been implicated in negative symptoms. Repetitive transcranial magnetic stimulation is efficacious for the negative symptoms. Deep transcranial magnetic stimulation (dTMS)…
Alcohol Use Disorder (AUD) is associated with elevated brain response to cues. Recent studies have suggested that theta burst stimulation (TBS) to the MPFC can decrease reactivity to cues in a transdiagnostic manner. Objective: To evaluate the effect of continuous TBS as…
Negative symptoms of schizophrenia are disabling and often show inadequate response to antipsychotic treatment. Dysfunction in cortical regions such as the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) has been implicated in these symptoms. While repetitive transcranial magnetic stimulation (rTMS)…
Patients with schizophrenia have a high prevalence of cigarette smoking and respond poorly to conventional treatments, highlighting the need for new therapies. Objective: This was a mechanistic, proof-of-concept study using bilateral deep repetitive transcranial magnetic stimulation (dTMS) of insular and prefrontal cortices…
TMS holds promise for posttraumatic stress disorder (PTSD); while recent randomized controlled trials have provided mixed evidence (e.g., [4–6]), large-scale effectiveness data strongly supports the use of standard TMS for those who have PTSD comorbid with MDD. Objective: This study examined the…
PTSD patients have hypo-activity in the mPFC during traumatic recall. Stimulating the mPFC with dTMS after an individualized traumatic script was effective in decreasing PTSD symptoms in a double blinded placebo-controlled study. Objective: A retrospective case series treating patients with PTSD comorbid with severe depression who were ineligible for a…
PTSD is both prevalent and debilitating. While Deep TMS has shown preliminary efficacy, exposure therapy remains the most efficacious, though limited, treatment in PTSD. The medial prefrontal cortex (mPFC) is implicated in extinction learning, suggesting that concurrent mPFC stimulation may enhance exposure therapy. Objective: This randomized controlled multicenter trial set out…
