Sequential L-PFC, DMPFC-ACC, Accelerated Intermittent Theta Burst Deep TMS for Suicidal Highly Treatment Resistant Depression Patients

Journal: Brain Stimulation 11: e1-e8 (2018)

Authors: A Tendler, E Sisko, N Rodriguez, S Corbett-Methot, J Sutton-DeBord, J Brown, N Williams

Background:

Depressed, suicidal patients who failed pharmacologic andbrain stimulation protocols have significant hopelessness about futuretreatment, making a four-week treatment protocol particularly challenging.

Objective:

Testing the safety and efficacy of accelerated intermittent theta burst (iTBS) to the left PFC (L-PFC) and dorsomedialprefrontal cortex-anterior cingulate cortex (dmPFC-ACC), two regionsassociated with antidepressant Deep TMS™ response.

Methods:

Seven severely depressed, suicidal patients, who failed pharmacotherapy and a course of Deep TMS, were given 108,000 pulses over three to four days. Deep TMS was administered at 30-50HZ in 3 pulse bursts, 10bursts over two seconds (5HZ), followed by a five second interval, for 60 cycles (1800P over 7 minutes) with the H1 coil over the L-PFC at 90% resting hand MT followed by the H7 over the dmPFC-ACC at 90% resting foot MT.After 15-minutes from the end of H1 treatment, the cycle was repeated 10 times per day for three days. Progress was assessed with the SSI, IDS, and CGI-S at baseline and later time points. Significance was evaluated with paired t-tests.

Results:

90%MT sequential dual target accelerated iTBS was well tolerated with headaches, jaw movements and scalp discomfort as adverse events. By day ten, suicidality decreased in 7/7 patients (Mean % decrease SSI=21.97%±SD=25.61). The five patients’depression responded and the two were non-responders by IDS-SR30 (Mean % decrease IDS-SR30=56.02%±SD=21.96) and CGI-S criteria (Mean decrease CGI-S=3.57±SD=2.23). The two non-responders only tolerated 80%MT iTBS.

Conclusions:

Accelerated sequential L-PFC, dmPFC-ACC 90%MTiTBS appears safe and helpful for suicidal patients. Controlled studies are warranted.