Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Journal: Frontiers in Neurology 6:16 (2015)

Authors: C Rapinesi, F.S Bersani, G.D Kotzalidis, C Imperatori, A Del Casale, S Di Pietro, V.R Ferri, D Serata, R.N Raccah, A Zangen, G Angeletti, P Girardi

Background:

Deep transcranial magnetic stimulation (Deep TMS™) is a new form of TMS allowing safe stimulation of deep brain regions.

Objective:

The objective of this preliminary study was to assess the role of Deep TMS maintenance sessions in protecting patients with bipolar disorder (BD) or recurrent major depressive disorder (MDD) from developing depressive or manic relapses in a 12-month follow-up period.

Methods:

Twenty-four drug-resistant patients with a current depressive episode and a diagnosis of MDD or BD have been enrolled in the study. All the participants underwent daily Deep TMS sessions for 4 weeks. One group (maintenance –M group) received additional maintenance Deep TMS sessions weekly or twice a week.

Results:

After the first Deep TMS cycle, a significant reduction of Hamilton Depression Rating Scale (HDRS) scores was observed in all participants. Subsequently, the HDRS mean scores did not significantly change over time in the M group, while it significantly increased in the non-M-group after 6 and 12 months.

Conclusions:

This study confirms previous evidence of a positive therapeutic effect of Deep TMS on depressive symptoms and suggests that, after recovery from acute episodes, maintenance Deep TMS sessions may be helpful in maintaining euthymia in a 12-month follow-up period.

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