Brainsway Deep TMS Therapy - for Brain Disorder Treatment

Publications - Major Depressive Disorder Treatment

View publications relating to Brainsway's major depressive disorder treatment and treatment resistant depression. Brainsway Deep TMS has been widely researched for treating major depressive disorder, as seen in the following.

  • Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial

    Levkovitz Y, Isserles M, Padberg F, Lisanby SH, Bystritsky A, Xia G, Tendler A, et al. Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial. World Psychiatry 2015;14(1):64-73.

    This multicenter study examined Brainsway® Deep TMS (Transcranial Magnetic Stimulation) as a treatment for major depressive disorder. The study included over 200 patients who were randomly assigned for real or sham Deep TMS (20 sessions) over a period of a month.

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  • H-coil repetitive transcranial magnetic stimulation for treatment resistant major depressive disorder: An 18-week continuation safety and feasibility study

    Harel, E. V., Rabany, L., Deutsch, L., Bloch, Y., Zangen, A., & Levkovitz, Y. (2014). The World Journal of Biological Psychiatry, 15(4), 298-306.

    This study examined the long-term effect of Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) on depressed patients. Patients underwent 4 weeks of intensive treatment and 18 weeks of maintenance treatments. The study demonstrated that brain stimulation using Brainsway's Deep Transcranial Magnetic Stimulation significantly alleviates depressive symptoms, and that this beneficial effect can be maintained for a long period of time.

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  • Effectiveness of a second deep TMS in depression: A brief report

    Rosenberg, O., Isserles, M., Levkovitz, Y., Kotler, M., Zangen, A., & Dannon, P. N. (2011). Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(4), 1041-1044.

    This study examined the effect of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on depressed patients which previously benefited from the treatment but suffered from deterioration. The patients were given 20 daily sessions of stimulation, resulting in a significant decrease in HDRS, HARS and BDI scores, although at a lesser rate compared to the decrease during the first Deep TMS treatment period. In this study it was demonstrated that a second treatment period of brain stimulation using the H-coil significantly alleviates depressive symptoms.

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  • Differential effects of deep TMS of the prefrontal cortex on apathy and depression‏

    Levkovitz, Y., Sheer, A., Harel, E. V., Katz, L. N., Most, D., Zangen, A., & Isserles, M. (2011). Brain stimulation, 4(4), 266-274.

    This study examined the effect of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil stimulation on depressed patients, and evaluated separately the effect on depressive symptoms and on one of depression's core symptoms - apathy. In the study, antidepressant medication treatment was ceased, and Deep Transcranial Magnetic stimulation was given 5 days a week, over 4 weeks. The study demonstrated that brain stimulation using the Deep TMS H-coil significantly alleviates depressive symptoms including apathy, but only if pre-treatment apathy was not very severe.

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  • Cognitive – emotional reactivation during deep transcranial magnetic stimulation over the prefrontal cortex of depressive patients affects antidepressant outcome

    Isserles, M., Rosenberg, O., Dannon, P., Levkovitz, Y., Kotler, M., Deutsch, F., & Zangen, A. (2011). Journal of affective disorders, 128(3), 235-242.

    This study examined the effect of the Transcranial Magnetic Stimulation H-coil on patients suffering from depression, following positive or negative emotional triggering. This was done by focusing the patients on either positive or negative thoughts or emotions associated with the patient's depression. In this study, it was demonstrated that positive, rather than negative, emotional triggering prior to brain stimulation using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil results in more favorable treatment outcomes. 

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  • Deep TMS in a resistant major depressive disorder: a brief report

    Rosenberg, O., Shoenfeld, N., Zangen, A., Kotler, M., & Dannon, P. N. (2010). Depression and anxiety, 27(5), 465-469.

    This study examined the effect of the Brainsway® Deep Transcranial Magnetic Stimulation H-coil as an add-on treatment for patients suffering from drug-resistant depression. The study comprised depression patients, and treated them with Brainsway Deep Transcranial Magnetic Stimulation H1-coil, which was connected to a Magstim rapid 2 stimulator.

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  • Deep transcranial magnetic stimulation over the prefrontal cortex: Evaluation of antidepressant and cognitive effects in depressive patients

    Levkovitz, Y., Harel, E. V., Roth, Y., Braw, Y., Most, D., Katz, L. N., & Zangen, A. (2009). Brain Stimulation, 2(4), 188-200.

    This is the first clinical study using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil for deep brain stimulation. This large scale study examined the effect of H-coil on patients suffering from drug-resistant depression. The study found a significant improvement in HDRS scores in the cases of high-intensity stimulation.

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  • A randomized controlled feasibility and safety study of deep transcranial magnetic stimulation

    Levkovitz, Y., Roth, Y., Harel, E. V., Braw, Y., Sheer, A., & Zangen, A. (2007). Clinical Neurophysiology, 118(12), 2730-2744.

    This study examined possible effects of different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and different stimulation parameters on healthy individuals. Several parameters relating to health, cognitive and emotional issues were checked .Results were also compared to a standard coil (figure 8) and to a sham coil. This study demonstrated that brain stimulation using the H-coil is feasible, safe and without adverse consequences. 

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  • Three-Dimensional Distribution of the Electric Field Induced in the Brain by Transcranial Magnetic Stimulation Using Figure-8 and Deep H-Coils

    Roth, Y., Amir, A., Levkovitz, Y., & Zangen, A. (2007). Journal of Clinical Neurophysiology, 24(1), 31-38.

    This study compares the penetration depths of two different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and a standard coil (Figure 8 coil). In the study, electrical fields of H-coils and of a Figure 8 coil were measured using a head model. This study demonstrates that the H-coil is able to reach significantly deeper brain areas than those reached by the figure-of-8 coil. Also, it was shown that the H-coils allow for stimulation of several brain regions at the same time.

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  • Transcranial Magnetic Stimulation of Deep Brain Regions:Principles and Methods.

    Roth, Y., Padberg, F., & Zangen, A. (2007). In “Transcranial Brain Stimulation for Treatment of Psychiatric Disorders” (Vol. 23).

    This book chapter describes the biological and physical components that participate in the effects of Brainsway®'s Deep TMS (Transcranial Magnetic Stimulation) H-Coil for brain stimulation. 

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