Brainsway Deep TMS Therapy - for Brain Disorder Treatment

Neural Predictors and Longitudinal Neural Correlates of Clinical Improvement after Standard or Deep Transcranial Magnetic Stimulation in Major Depression: A Randomized Study

McGill University Hospital, Montreal, Canada

7 July 2013

Deep TMS allows direct stimulation of much larger and deeper brain regions, has been shown to be effective and safe in treating MDD. Neuroimaging studies have shown that standard HF-rTMS directly affects several superficial areas of the brain, but to date there is no data on the brain effects of Deep TMS. Thus, this study aims to explore, for the first time, the brain effects of Deep TMS in MDD. More specifically, we, the investigators, hope to identify possible neural predictors of clinical improvement after Deep TMS and also clarify the impact of Deep TMS in the brain activity over time. In this study, Deep TMS will be applied over the left side of the front of the head (a region known as the 'prefrontal cortex'), and will be compared with standard HF-TMS in terms of its effectiveness and brain effects. For this, 80 subjects with at least moderate MDD will be randomized to receive daily Deep TMS or standard HF-rTMS treatment for 4 weeks, and will undergo functional magnetic resonance imaging (fMRI) before and after treatment. During the fMRI sessions, we will use two validated cognitive tasks. Our results could eventually lead us, among other things, to identify which depressed patients would be best candidates for receiving either standard rTMS or Deep TMS, and which areas of the brain should be targeted by these neuromodulation techniques.

Contact: MARCELO T. BERLIM, M.D., M.Sc   Tel: 514 761 -6131 - ext. 3301 mberlim@me.com

Principal Investigator: MARCELO T. BERLIM, M.D., M.Sc   


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