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The Influence of Deep Repetitive Transcranial Magnetic Stimulation (TMS) on Cerebellar Signs in Patients With Spinocerebellar Ataxia Type 3 (SCA3 - Machado Joseph Disease)

Meir Hospital, Kfar-Saba, Israel

13 March 2014

The purpose of this study is to test the effects of low frequency deep rTMS using the novel HCERMJD-coil on cerebellar deficits in patients with SCA3 and to establish its safety in this population. We anticipate that stimulation of the cerebellum with the novel HCERMJD-coil may induce significantly therapeutic effects in patients with SCA3 and will pave the way for establishing a novel and effective treatment for this disorder.

SCA3 is characterized by a progressive process of neurodegeneration particularly in the cerebellum and, brainstem. Basal ganglia and cerebral cortex atrophy have also been reported in some cases and Many MRI studies have shown the correlation between the cerebellum and MJD. There is no any efficient treatment to reduce or alter the process of neurodegeration and no any means to stimulate plasticity of still functioning connection to improve cerebellar function.

We propose that stimulation of the cerebellum with the novel H-coil may induce significantly therapeutic effects in patients with SCA3 and will pave the way for establishing a novel and effective treatment for this disorder.

Many studies have shown that in MJD patient there is hyperexcitability in the peripheral motor axons, which results from the hyperexcitability of the cerebellum, and the same pattern were shown in animal studies. We therefore designed an open study aimed to test the effects of low frequency deep rTMS using the novel HCERMJD-coil on cerebellar function in patients with SCA3 as well as to establish its safety in this population.

Contact: Prof. Carlos Gordon, Carlos.Gordon@clalit.org.il

Principal Investigator: Prof. Carlos Gordon


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