CAMH, Toronto, Canada
1 March 2014
We will use the Deep repeated Transcranial Magnetic Stimulation (rTMS) approach to interfere with insula activity in humans. We will test whether low- and high-frequency rTMS of the insula produces any effect on striatal DA release. For this, we will use Deep rTMS with different parameters (1Hz and 10Hz). To assess the impact of rTMS on DA levels, we will use Positron Emission Tomography (PET) and the [11C]-(+)-PHNO radiotracer, developed at CAMH by the co-applicant Dr Wilson, which is very sensitive to fluctuation of DA transmission in human brain. This innovative project will produce the first data in humans linking the insula to the DA system in vivo. These basic findings could lead to identifying optimal parameters of Deep rTMS to use secondarily in a proof of principle clinical study in smokers.
Contact: Saima Malik, Ph.D Tel. 416. 535. 8501 ext. 36581 Saima.Malik@camh.ca
Principal Investigator: Bernard Le Foll, MD PhD CCFP