Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a person's mood, energy, and ability to function. Different from the normal ups and downs that everyone goes through, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and even suicide. About 5.7 million American adults or about 2.6 percent of the population age 18 and older in any given year, have bipolar disorder.
Bipolar disorder typically develops in late adolescence or early adulthood. However, some people have their first symptoms during childhood, and some develop them late in life. It is often not recognized as an illness, and people may suffer for years before it is properly diagnosed and treated. Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person's life. As bipolar disorder is associated with pathologies within the reward system, repeated activation of prefrontal regions and the deeper reward-related network innervated by the prefrontal cortex by Deep TMS, may allow effective treatment of this chronic disease.
Current treatments: Conventional treatments include various combinations of antidepressants and mood-stabilizers (such as lithium). However, there is no consensus and very limited clinical data regarding both the effectiveness of these treatments and the possibility that antidepressant medication might exacerbate the intensity and frequency of manic episodes in bipolar patients. Treatment with conventional antidepressant medication may trigger a manic attack or accelerate the bipolar cycle1. ECT is administered as a treatment in cases of treatment-resistant manic or depressive episodes, or in cases where medication produces severe side effects.
The final report of a previous clinical trial conducted by Brainsway's states that all subjects took the treatment well, and 70% of the subjects responded to the treatment (a vast majority of same with significant improvement) as compared with previous treatment with anti-depressants that were given to the subjects (see link below...)
Brainsway's Clinical Trials:
 Antai-Otong D.Treatment considerations for patients experiencing rapid-cycling bipolar disorder. Perspect Psychiatr Care. 2006 Feb;42(1):55-8